Results 101 to 110 of about 3,510,874 (207)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Crustins: enigmatic WAP domain-containing antibacterial proteins from crustaceans [PDF]

, 2008
Crustins are antibacterial proteins of ca. 7–14 kDa with a characteristic four-disulphide core-containing whey acidic protein (WAP) domain, expressed by the circulating haemocytes of crustaceans.
Smith, Valerie J., Fernandes, Jorge M.O., Fernandes, J M O, Kemp, Graham D., Hauton, Chris   +4 more
core   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena

Epigenetics & Chromatin
Background INO80 and SWR1 are evolutionarily related ATP-dependent chromatin remodeling complexes that regulate the chromatin occupancy of the histone variant H2A.Z, playing critical roles in transcriptional regulation, genome replication, and DNA repair.
Jyoti Garg, Alejandro Saettone, Syed Nabeel-Shah, Steven Dang, Abdul Hadi Khalid, Jérémy Loehr, Alexandra Petrova, James D. Burns, Peter Karabatsos, Sherin Shibin, Suzanne Wahab, Sean D. Taverna, Jack F. Greenblatt, Jean-Philippe Lambert, Jeffrey Fillingham   +14 more
doaj   +1 more source

Genetic Architecture of Southern Stem Canker Resistance in Elite Southern Soybean (Glycine max [L.] Merr.) Germplasm

Plant Breeding, EarlyView.
ABSTRACT Southern stem canker (SSC), caused by the fungus Diaporthe aspalathi, is one of the major constraints to soybean (Glycine max [L.] Merr.) production in the southern United States and South America. Genetic resistance is the most effective strategy for managing SSC; however, the genetic architecture underlying resistance in elite southern ...
M. Habib Widyawan, James W. Buck, Qijian Song, Zenglu Li   +3 more
wiley   +1 more source

Role for Bromodomain‐Containing Protein 4 in Pulmonary Arterial Hypertension

The FASEB Journal, 2015
Background Pulmonary arterial hypertension (PAH) is associated with sustained DNA damage accounting for a PARP‐1‐dependent downregulation of miR‐204, promoting the expression of oncogenes (Survivin, Pim‐1). Once activated through the transcription factor NFAT, they contribute to the pro‐proliferative and anti ...
Mylène Vaillancourt, Jolyane Meloche, Grégoire Ruffenach, Steeve Provencher, Sébastien Bonnet   +4 more
openaire   +1 more source

Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives

Plant, Cell &Environment, EarlyView.
ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley   +1 more source