Results 91 to 100 of about 3,510,874 (207)

Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins

, 2016
Chromatin modifying proteins are attractive drug targets in oncology, given the fundamental reliance of cancer on altered transcriptional activity. Multiple transcription factors can be impacted downstream of primary target inhibition, thus making it ...
Daniel E. Spratt (1385634), Michael J. Evans (530452), Charles L. Sawyers (172042), Michael G. Doran (1385631), John Wongvipat (228488), Charles Truillet (1355238), Kathryn E. Carnazza (1385628), Jeffrey M. Steckler (1385637), Jason S. Lewis (254218)   +8 more
core   +1 more source

BRWD3 (bromodomain and WD repeat domain containing 3) [PDF]

, 2007
Review on BRWD3 (bromodomain and WD repeat domain containing 3), with data on DNA, on the protein encoded, and where the gene is ...
Kalla, C
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition

Nature Communications
Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains.
Noha A. M. Shendy, Melissa Bikowitz, Logan H. Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M. Delahunty, Sarah Robinson, Vanshita Goel, Matthew G. Rees, Melissa A. Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A. Roth, Yingzhe Wang, Burgess B. Freeman, Brent A. Orr, Brian J. Abraham, Martine F. Roussel, Ernst Schonbrunn, Jun Qi, Adam D. Durbin   +23 more
doaj   +1 more source

BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes

Frontiers in Oncology, 2019
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells present genetic
Fernando Vieira Pericole, Mariana Lazarini, Mariana Lazarini, Luciana Bueno de Paiva, Adriana da Silva Santos Duarte, Karla Priscila Vieira Ferro, Fernanda Soares Niemann, Fernanda Marconi Roversi, Fernanda Marconi Roversi, Sara Teresinha Olalla Saad   +9 more
doaj   +1 more source

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

Frontiers in Molecular Neuroscience
IntroductionGiven the complex etiological basis of Alzheimer’s disease (AD), it is reasonable to hypothesize that neuronal dysfunction and death result from the interplay of numerous factors, both genetic and environmental.
Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Gabriela Olech-Kochańczyk, Ewelina Pałasz, Elżbieta Gawinek, Marcin Strawski, Grzegorz A. Czapski   +8 more
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Bromodomain-containing proteins (BDPs) are involved in the regulation of eukaryotic gene expression. Compounds that bind and/or inhibit BDPs are of interest as tools to better understand epigenetic regulation, and as possible drug leads for different ...
Ming Jang Chua, Dina Robaa, Tina S. Skinner-Adams, Wolfgang Sippl, Katherine T. Andrews   +4 more
doaj   +1 more source