Results 111 to 120 of about 3,510,874 (207)

The tripartite motif-containing 24 is a multifunctional player in human cancer

Cell & Bioscience
Tripartite motif-containing 24 (TRIM24), also known as transcriptional intermediary factor 1α (TIF1α), is the founding member of TIF1 family. Recent evidence indicates that aberrant expression of TRIM24, functions as an oncogene, is associated with poor ...
Yuanbing Yao, Sheng Zhou, Yue Yan, Kai Fu, Shuai Xiao   +4 more
doaj   +1 more source

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

Epigenetics, 2018
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET ...
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara   +13 more
doaj   +1 more source

Genome‐Wide Association Analysis of Hippocampal Neuroplasticity as an Indicator of Stress Responsiveness in Laying Hens (Gallus gallus domesticus)

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Environmental stressors in commercial poultry systems can negatively affect bird welfare, although individuals vary considerably in their responses. Neuroplasticity within the hippocampus, measured through the density of doublecortin‐positive (DCX+) neurons, provides a potential biomarker of stress experience in laying hens.
Lindsay Neuert, Vern Osborne, Elena A. Armstrong, Fábio Pértille, Carlos Guerrero Bosagna, Timothy Boswell, Tom V. Smulders, Christine F. Baes, Bayode O. Makanjuola   +8 more
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

Bromodomain-containing protein 4 in inflammatory diseases: molecular mechanisms and therapeutic potential

Journal of Inflammation
Bromodomain-containing protein 4 (BRD4), a key member of the bromodomain and extra-terminal (BET) family, plays a critical role in regulating gene expression as an epigenetic reader.
Rachele Frascatani, Irene Marafini, Marco Colella, Giovanni Monteleone   +3 more
doaj   +1 more source

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, Volume 48, Issue 10, Page 2810-2820, October 2026.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley   +1 more source

tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.

PLoS ONE, 2014
Multicellular organisms have evolved specialized mechanisms to control transcription in a spatial and temporal manner. Gene activation is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains.
Ina Theofel, Marek Bartkuhn, Tim Hundertmark, Thomas Boettger, Stefanie M K Gärtner, Katja Leser, Stephan Awe, Michael Schipper, Renate Renkawitz-Pohl, Christina Rathke   +9 more
doaj   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source