Results 131 to 140 of about 16,709 (213)
Liver International, Volume 46, Issue 7, July 2026.ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley +1 more source
Bromodomain-containing proteins in the unicellular eukaryote Tetrahymena thermophila.
Zoological researchBromodomain (BRD)-containing proteins are central mediators of gene regulation, serving as key components of chromatin remodeling complexes and histone recognition scaffolds. By specifically recognizing acetylated lysine residues on histones (Kac) via their conserved BRD, these proteins influence chromatin structure and gene expression.
Zhang, Zhe +5 more
openaire +2 more sources
Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells
Drug Design, Development and Therapy, 2018 Zhen Tan,* Xiuli Zhang,* Ting Kang, Lian Zhang, Siyu Chen Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China *These authors contributed equally to this work Purpose: Gastric and colon ...
Tan Z, Zhang X, Kang T, Zhang L, Chen S
doaj
Double bromodomain proteins as regulators of lymphopoiesis and inflammation
, 2012 Thesis (Ph.D.)--Boston UniversityHistone post-translational modifications are essential for the regulation of gene expression. These modifications are recognized by chromatin "readers" that control gene co-activation and co-repression through intrinsic ...
Belkina, Anna
core
Frontiers in MicrobiologyChagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose ...
Victoria L. Alonso +12 more
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Frontiers in Bioscience-LandmarkBackground: As a major contributor to cancer-associated deaths, advanced colorectal cancer (CRC) has a constrained range of effective treatment options.
Chenlu Wang +4 more
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Bromodomain and extra-terminal domain (BET) proteins play an important role in epigenetic regulation and are linked to several diseases; therefore, they are interesting targets. BET has two bromodomains: bromodomain 1 (BD1) and BD2.
Mingsong Shi (6560306) +13 more
core +1 more source
Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites
, 2015 Bromodomains are readers of the epigenetic code that specifically bind acetyl-lysine containing recognition sites on proteins. Recently the BET family of bromodomains has been demonstrated to be druggable through the discovery of potent inhibitors ...
Stefan Knapp (244328) +3 more
core +1 more source