Results 131 to 140 of about 3,510,874 (207)

Proteins

, 2004
Solvation energy calculation is one of the main difficulties for the estimation of protein-ligand binding free energy and the correct scoring in docking studies.
Zhou, JJ, Wang, Q, Pei, JF, Lai, LH
core   +1 more source

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3)

Frontiers in Microbiology
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose ...
Victoria L. Alonso, Victoria L. Alonso, Andrea M. Escalante, Elvio Rodríguez Araya, Elvio Rodríguez Araya, Gianfranco Frattini, Gianfranco Frattini, Luis E. Tavernelli, Diego M. Moreno, Diego M. Moreno, Ricardo L. E. Furlan, Esteban Serra, Esteban Serra   +12 more
doaj   +1 more source

Bromodomain-Containing Protein 2 [PDF]

, 2020
openaire   +1 more source

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

, 2015
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy.
Cassel, M. K., Adhikari, N., Urick, A. K., Mishra, N. K., Hawk, L. M., Liu, S., Dos Santos, C. O., Zhang, W., Hall, J. L., Pomerantz, W. C.   +9 more
core   +1 more source

Role of bromodomain containing proteins in the DNA damage response

, 2018
Chromatin-based DNA damage response (DDR) mechanisms are fundamental for preventing genome and epigenome instability, which are hallmarks of cancer.
Gong, Fade
core   +1 more source

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.

, 2014
Bromodomains (BRDs) are protein modules which bind to acetylated lysines on histones and transcriptional regulating proteins. BRD-containing proteins are involved in a large variety of critical cellular processes and their misregulation, or mutation of the genes encoding for them, has been linked to pathogenesis in humans.
openaire   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain-Containing Proteins. [PDF]

Chembiochem
Scholtz CR, Pomerantz WCK.
europepmc   +1 more source

Bromodomain-containing proteins in the unicellular eukaryote <i>Tetrahymena thermophila</i>. [PDF]

Zool Res
Zhang Z, Ju AL, Wang YY, Jiang HZ, Liu YQ, Gao S.   +5 more
europepmc   +1 more source

Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). [PDF]

Mol Cell Proteomics, 2015
Mackmull MT, Iskar M, Iskar M, Parca L, Singer S, Bork P, Ori A, Beck M.   +7 more
europepmc   +1 more source

The Systematic Comparison of Enhancer of Zeste Homolog-2-, Bromodomain-containing Proteins-, Histone Deacetylase-, and DNA-methyltransferase 1-inhibitors in a Syngeneic Murine Model of Melanoma Reveals Differential Anti-tumoral and Immunomodulatory Activities. [PDF]

MedComm (2020)
Rigo V, Amaro A, Reggiani F, Fenoglio D, Martini S, Altosole T, Petito M, Profumo C, Croce M.   +8 more
europepmc   +1 more source