Global chemoproteomic profiling of bromodomain inhibitors
Bromodomain-containing proteins (BCPs) are epigenetic readers that regulate gene expression and play key roles in many diseases including cancer, making them prime targets for drug discovery. While several high-quality chemical probes and inhibitors have
Bauer, Ludwig Gerhard
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Histone post-translational modifications (PTMs) serve as an epigenetic signaling mechanism that regulates gene expression. Two of the most prevalent PTMs are acetylation, which can activate gene expression, and methylation, which can activate or repress ...
Cook, Elizabeth
core
Bromodomain-containing proteins in the unicellular eukaryote <i>Tetrahymena thermophila</i>. [PDF]
Zool ResZhang Z +5 more
europepmc +1 more source
Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). [PDF]
Mol Cell Proteomics, 2015 Mackmull MT +7 more
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The Systematic Comparison of Enhancer of Zeste Homolog-2-, Bromodomain-containing Proteins-, Histone Deacetylase-, and DNA-methyltransferase 1-inhibitors in a Syngeneic Murine Model of Melanoma Reveals Differential Anti-tumoral and Immunomodulatory Activities. [PDF]
MedComm (2020)Rigo V +8 more
europepmc +1 more source
Parasite-specific essential bromodomain protein TgBDP4 is a key epigenetic reader and a potential drug target for the parasite Toxoplasma gondii. [PDF]
J Biol ChemGurupwar R, Khandavalli CR, Deshmukh AS.
europepmc +1 more source
Development of a Lysine-Reactive Targeted Covalent Inhibitor for the P300/CBP-Associated Factor Bromodomain Through Structure-Based Design. [PDF]
ChemMedChemEde RR +9 more
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