NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells. [PDF]
Bioconjug ChemSneddon MS +4 more
europepmc +1 more source
TIF1 Family Proteins as Modulators of Cell Death: Mechanisms and Therapeutic Opportunities. [PDF]
BiomoleculesYang D, Chen Y.
europepmc +1 more source
Discovery of molecular glues that bind FKBP12 and structurally distinct targets using DNA-encoded libraries. [PDF]
Nat CommunZandi TA +9 more
europepmc +1 more source
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. [PDF]
Nat CommunCapponi S +9 more
europepmc +1 more source
Stabilizing Plasmodium falciparum proteins for small molecule drug discovery. [PDF]
Protein SciAmann M +3 more
europepmc +1 more source
The dual role of BRD9 in cancer: Mechanistic insights and therapeutic prospects. [PDF]
iScienceLi J +9 more
europepmc +1 more source
From Epigenetic Regulation to Protein Degradation: Emerging Strategies for Anti-Infective Drug Discovery. [PDF]
Int J Mol SciBonjorno AF +7 more
europepmc +1 more source
TARGETING BROMODOMAIN-CONTAINING PROTEIN 4 IN ABDOMINAL AORTIC ANEURYSM
Bromodomain containing protein 4 (BRD4) belongs to the bromodomain and external domain family of proteins. It is crucial for the transcriptional regulation of various immune responses and cell survival processes.
Lopez, Javier
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Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven <i>KLF6</i> expression in renal carcinoma. [PDF]
Oncol RepZamberi NNM +5 more
europepmc +1 more source
BET bromodomain inhibitors are very promising novel anticancer agents, however, single therapy does not cause tumor regression in mice, suggesting the need for combination therapy. After screening a library of 2697 small molecule compounds, we found that
Bernard Atmadibrata (524472) +25 more
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