Results 171 to 180 of about 3,510,874 (207)

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery. [PDF]

Protein Sci
Amann M, Sträßer T, Einsle O, Günther S.   +3 more
europepmc   +1 more source

From Epigenetic Regulation to Protein Degradation: Emerging Strategies for Anti-Infective Drug Discovery. [PDF]

Int J Mol Sci
Bonjorno AF, Boreski D, Rodriguez Gini AL, Souza Tada da Cunha P, Moura JA, Chin CM, Benito Scarim C, Dos Santos JL.   +7 more
europepmc   +1 more source

Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven <i>KLF6</i> expression in renal carcinoma. [PDF]

Oncol Rep
Zamberi NNM, Abuhamad AY, Yusuf SNHM, Rahman NQAA, Mohtar MA, Syafruddin SE.   +5 more
europepmc   +1 more source

Histone modification cross-talk: analytical tools and molecular mechanisms. [PDF]

Biochem J
Jiang J, DuBois-Coyne S, Nam E, Whedon SD, Lee K, Cole PA.   +5 more
europepmc   +1 more source

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The Role of Bromodomain-Containing Proteins in Development and Disease

Current Molecular Biology Reports, 2023
Tapan Sharma
exaly   +2 more sources

Functional Roles of Bromodomain Proteins in Cancer

Cancers, 2021
Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the
Karen C Glass, Hana Paculova, Sam Boyson
exaly   +2 more sources

Privileged Scaffolds Targeting Bromodomain-containing Protein 4

Current Topics in Medicinal Chemistry, 2022
Abstract: In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) family, has been one of the most widely studied targets. BRD4 is a transcriptional regulation factor, which regulates cell transcription, marks mammalian biological mitosis, regulates cell cycle, and plays an important role ...
Ru, Wang, Yi-Ang, Wang, Yun-Gen, Xu, Lei, Shi   +3 more
openaire   +2 more sources

Research Progress of Selective Small Molecule Bromodomain-Containing Protein 9 Inhibitors

Future Medicinal Chemistry, 2018
The bromodomain proteins, known as the key targets in epigenetics, are ‘readers’ of acetylated lysine of histones. As a member of bromodomain proteins, bromodomain-containing protein 9 (BRD9) is a subunit of mammalian SWI/SNF chromatin remodeling ...
Zheng Peiyuan, Zhang Jian, Zhang Huibin, Ma Hui, Wu Zhenwei   +4 more
exaly   +2 more sources

Bromodomain-Containing Protein 4: A Druggable Target

Current Drug Targets, 2019
Bromodomain-containing protein 4 (BRD4) belongs to the bromodomain and extraterminal family. BRD4 inhibitors can regulate acetylated lysine and form protein complexes that initiate transcriptional programs as an epigenetic regulator of the histone code. BRD4 was initially considered to be one of the most promising targets for combating malignant tumors.
Yingying, Shi, Jingwen, Liu, Yuanyuan, Zhao, Jiaoxian, Cao, Yiming, Li, Fujiang, Guo   +5 more
openaire   +2 more sources

Acetyllysine-binding and function of bromodomain-containing proteins in chromatin

Frontiers in Bioscience, 2001
Acetylated histones are generally associated with active chromatin. The bromodomain has recently been identified as a protein module capable of binding to acetylated lysine residues, and hence is able to mediate the recruitment of factors to acetylated chromatin. Functional studies of bromodomain-containing proteins indicate how this domain contributes
M H, Dyson, S, Rose, L C, Mahadevan
openaire   +3 more sources