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Bromodomain‐containing protein 4 and its role in cardiovascular diseases
Journal of Cellular Physiology, 2020AbstractBromodomain‐containing protein 4 (BRD4), a chromatin‐binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy.
Liang Li +3 more
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Hypothetical bromodomain-containing protein 5 is required for the growth of Toxoplasma gondii
Veterinary Parasitology, 2022Bromodomain (BRD) is a highly conserved structural module domain, found in various proteins, including chromatin-related proteins, nucleus acetyltransferases, and transcription-associated proteins. Toxoplasma gondii, a zoonotic protozoan, encodes at least 12 predicted BRD-containing proteins (BDPs).
Ying, Zhang +9 more
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Targeting bromodomain-containing proteins to prevent spontaneous preterm birth
Clinical Science, 2019Abstract Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non ...
Ratana Lim +2 more
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Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis
Immunology Letters, 2015We aimed to explore the effects of bromodomain-containing protein 4 (BRD4) inhibition on tumor necrosis factor (TNF)-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) behavior and the therapeutic implications using BRD4 inhibitor JQ1 were explored in vivo.
Qing-gang, Zhang +2 more
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Clinical Significance of Bromodomain-Containing Protein 9 in Colorectal Cancer
Annals of Surgical OncologySwitch/sucrose nonfermentable (SWI/SNF) complexes regulate gene expression through chromatin remodeling and include a recently reported subtype non-canonical BAF (ncBAF). The BRD9 gene that plays a central role in forming ncBAF has been reported to be a poor prognostic factor for various carcinomas.
Yoshinao Chinen +10 more
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Targeting Bromodomain-Containing Protein 9 in Human Uterine Fibroid Cells
Reproductive SciencesBromodomain (BRD)-containing proteins are evolutionarily conserved protein-protein interaction modules involved in many biological processes. BRDs selectively recognize and bind to acetylated lysine residues, particularly in histones, and thereby have a crucial role in the regulation of gene expression.
Qiwei Yang +4 more
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