Aberrant activation of epigenetic BRD9-DGAT1 axis promotes lipid droplets deposition and ferroptosis resistance in YAP-high prostate cancer. [PDF]
Cell Death DisZhu X +7 more
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Epigenetic suppression of synovial inflammation and osteoclast differentiation in rheumatoid arthritis by I-BET762. [PDF]
Sci RepKim RH, Choi SU, Song YW.
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A 5-Br-1-Propylisatin Derivative as a Promising BRD9 Ligand: Insights from Computational and STD NMR Investigation. [PDF]
MoleculesGazzillo E +5 more
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BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains. [PDF]
CellsSeitz C, Fu D, Liu M, Ma H, Liu J.
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Functional Roles of Bromodomain Proteins in Cancer
Cancers, 2021 Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the
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The Role of Bromodomain-Containing Proteins in Development and Disease
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Functions of bromodomain-containing proteins and their roles in homeostasis and cancer [PDF]
Nature Reviews Molecular Cell Biology, 2017 Bromodomains (BRDs) are evolutionarily conserved protein-protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues - particularly in histones - and thereby have important roles in the regulation ...
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Privileged Scaffolds Targeting Bromodomain-containing Protein 4
Current Topics in Medicinal Chemistry, 2022Abstract: In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) family, has been one of the most widely studied targets. BRD4 is a transcriptional regulation factor, which regulates cell transcription, marks mammalian biological mitosis, regulates cell cycle, and plays an important role ...
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Research Progress of Selective Small Molecule Bromodomain-Containing Protein 9 Inhibitors
Future Medicinal Chemistry, 2018 The bromodomain proteins, known as the key targets in epigenetics, are ‘readers’ of acetylated lysine of histones. As a member of bromodomain proteins, bromodomain-containing protein 9 (BRD9) is a subunit of mammalian SWI/SNF chromatin remodeling ...
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