Results 71 to 80 of about 743,371 (240)

Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker

Scientific Reports
This study investigated the anti-leukemic potential of BET inhibitors in combination with mTOR inhibitors, focusing on both BET-resistant and BET-sensitive AML cell lines.
Marcela Teatin Latancia, Wellington Fernandes da Silva, Elayne Bragança-Jardim, Fernanda Fernandes Terra, Paula Fontes Asprino, Welbert De Oliveira Pereira, Vanessa Candiotti Buzatto, Pedro Alexandre Galante, Lilian Tiemi Inoue, Ana Rita Fonseca, Thais Nascimento Kimmemgs, Celso Arrais-Rodrigues, Vanderson Rocha, Yana Novis, Niels Olsen Saraiva Camara, Ana Paula Lepique, Luiz Fernando Lima Reis, Mariane Tami Amano   +17 more
doaj   +1 more source

Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells.

PLoS ONE, 2022
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poor prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in HCC, suggesting epigenetic inhibition as a promising therapeutic approach.
Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

In Search of a Fair Bet in the Lottery [PDF]

Although state-operated lotto games have the worst average expected payoffs among common games of chance, because the jackpot can accumulate, the maximum expected payoff is potentially unlimited.
Kent Grote, Victor Matheson
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors

BRD4 and other members of the bromodomain and extraterminal (BET) family of proteins are promising epigenetic targets for the development of novel therapeutics.
Ernst Schönbrunn (1319238), Steven Gunawan (2105074), Norbert Berndt (1319235), Nicholas J. Lawrence (478700), Alice Chan (1823551), Jin-Yi Zhu (1319226), Andreas Becker (410057), Dylan Grassie (11620581), Rezaul Md Karim (8543853), Melissa J. Bikowitz (10668799)   +9 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 [PDF]

, 2017
The bromodomain and extra-terminal (BET) family of proteins, comprised of four members including BRD2, BRD3, BRD4 and the testis-specific isoform BRDT, largely function as transcriptional co-activators 1–3 and play critical roles in various cellular ...
Andrew H Beck, Pengda Liu, Huang, Jiaoti, Muthuswamy, Senthil, Rubin, Mark A., Kwok-Kin Wong, Ling Huang, Jiaoti Huang, Divya Vasudevan, Barbieri, Christopher E, Xiangpeng Dai, Xiaoning Li, James E Bradner, Christopher E Barbieri, Liu, Shengwu, Qing Zhong, Vasudevan, Divya, Hiroyuki Inuzuka, Shimizu, Kouhei, Ting Chen, Wong, Kwok-Kin, Francisco Beca, Beck, Andrew, Mark A Rubin, Dai, Xiangpeng, Liewei Wang, Wild, Peter J, Rubin, Mark A, Dennis L Buckley, Rubin, Mark Andrew, Qi, Jun, Wei, Wenyi, Garraway, Levi A, Chen, Ting, Senthil K Muthuswamy, Wenyi Wei, Guo, Jianping, Beck, Andrew H, Inuzuka, Hiroyuki, Yu Chen, Buser, Lorenz, Lorenz Buser, Shangqian Wang, Wang, Shangqian, Wang, Liewei, Muthuswamy, Senthil K, Wild, Peter J., Shengwu Liu, Zhang, Jinfang, Barbieri, Christopher E., Bradner, James E, Jinfang Zhang, Wei Zhang, Mirjam Blattner, Zhang, Wei, Huang, Ling, Li, Xiaoning, Levi A Garraway, Buckley, Dennis L., Wenjian Gan, Chen, Yu, Kouhei Shimizu, Buckley, Dennis L, Blattner, Mirjam, Peter J Wild, Zhong, Qing, Garraway, Levi, Beca, Francisco, Liu, Pengda, Jianping Guo, Jun Qi, Gan, Wenjian   +71 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Stability of the Bet v 1 cross-reactive allergens Api g 1 and Dau c 1 : a biophysical approach [PDF]

, 2009
The allergen Bet v 1 is known as the primary sensitizer for birch pollen-related food allergy and is responsible for IgE cross-reactivity to pathogenesis-related 10 (PR-10) proteins from, in particular, fruits from the Rosaceae and vegetables from the ...
Bollen, M.A.
core