Results 41 to 50 of about 100,083 (197)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pre-injury beta blocker use does not affect the hyperdynamic response in older trauma patients

Journal of Emergencies, Trauma and Shock, 2014
Purpose: Trauma dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the pre-injury cardiac medication profile influences admission physiology and post-injury ...
David C Evans, Kendrick M Khoo, Andrei Radulescu, Charles H Cook, Anthony T Gerlach, Thomas J Papadimos, Steven M Steinberg, Stanislaw PA Stawicki, Daniel S Eiferman   +8 more
doaj   +1 more source

PERIOPERATIVE BETA BLOCKER IN HIGH RISK PATIENTS UNDERGOING MAJOR ABDOMINAL SURGERY AND ITS EFFECT ON CARDIOVASCULAR MORTALITY AND MORBIDITY [PDF]

Ain Shams Medical Journal, 2019
Background: Perioperative cardiac complications are an important concern for the millions of individuals who undergo surgery worldwide every year. After surgery, 2% of these patients suffer major cardiac complications.
Lydia Zakhary, Rasha Hassan, Hoda Abdelsamie, Adel Alansary, Gehan Kamel   +4 more
doaj   +1 more source

The use of beta-blockers before major trauma and posttrauma outcome: A nationwide population-based study

Journal of Medical Sciences, 2022
Background: Beta-blockers are widely used for the treatment of arrhythmia, hypertension, and congestive heart failure. Major trauma causes significant blood loss and subsequent tachycardia and hypotension.
Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Po-Chuan Chen, Chin-Li Chen, Shih-Hung Tsai   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effectiveness of preJhospital betaJblocker therapy in patients with acute coronary syndrome

Российский кардиологический журнал, 2008
To assess the effectiveness of pre-hospital beta-blocker therapy in patients with acute coronary syndrome (ACS), 76 individuals with Q-wave myocardial infarction (Q-MI), and 62 persons with non-Q wave MI (non-Q-MI) were examined.
G. M. Baitova, Y. M. Madyarova, M. T. Beyshenkulov   +2 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure

Patient Preference and Adherence, 2016
Catherine Girouard,1–3 Jean-Pierre Grégoire,1–3 Paul Poirier,2,4 Jocelyne Moisan1–3 1Chair on Adherence to Treatments, Université Laval, 2Faculty of Pharmacy, Université Laval, 3Population Health and Optimal Health
Girouard C, Grégoire JP, Poirier P, Moisan J   +3 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Comparative study between oral and intralesional injection of beta-blocker in the treatment of infantile capillary hemangioma

Egyptian Pediatric Association Gazette
Purpose The present is conducted with the aim of comparing the clinical efficacy and side effects of oral versus intralesional propranolol treatment of infantile capillary hemangiomas.
Sahar S Sheta, Kareem B. Elessawy, Nadeen Eltoukhy, Ayman Esmail, Walaa ElNaggar   +4 more
doaj   +1 more source