Results 31 to 40 of about 61,745 (283)

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas) [PDF]

, 2011
This is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Eccles, PD, Giltrow, E, Hutchinson, TH, Rand-Weaver, M, Sumpter, JP   +4 more
core   +1 more source

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1993
The beta gamma subunits of heterotrimeric G proteins play important roles in regulating receptor-stimulated signal transduction processes. Recently appreciated among these is their role in the signaling events that lead to the phosphorylation and subsequent desensitization of muscarinic cholinergic (Haga, K., and Haga, T. (1992) J. Biol. Chem.
Walter J. Koch, James Inglese, W. Carl Stone, Robert J. Lefkowitz   +3 more
openalex   +4 more sources

Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation [PDF]

Cellular Signalling, 2016
β2-Adrenergic receptors (β2AR) transactivate epidermal growth factor receptors (EGFR) through formation of a β2AR-EGFR complex that requires activation of Src to mediate signaling. Here, we show that both lipid and protein kinase activities of the bifunctional phosphoinositide 3-kinase (PI3K) enzyme are required for β2AR-stimulated EGFR transactivation.
Lewis J. Watson, Kevin M. Alexander, Maradumane L. Mohan, Amber L. Bowman, Supachoke Mangmool, Kunhong Xiao, Sathyamangla V. Naga Prasad, Howard A. Rockman   +7 more
openalex   +3 more sources

Purification and characterization of the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1987
The beta-adrenergic receptor kinase (beta-ARK) is a recently discovered enzyme which specifically phosphorylates the agonist-occupied form of the beta-adrenergic receptor (beta-AR) as well as the light-bleached form of rhodopsin. beta-ARK is present in a wide variety of mammalian tissues.
M G Caron, Jeffery L. Benovic, Robert J. Lefkowitz, Federico Mayor, C Staniszewski   +4 more
openaire   +3 more sources

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source

Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation

OncoTarget, 2016
Activation of receptor tyrosine kinases (RTKs) is associated with carcinogenesis, but its contribution to smoking-associated lung carcinogenesis is poorly understood.
H. Min, Hye-Jin Boo, Ho Jin Lee, Hyun-Ji Jang, H. Yun, S. Hwang, J. K. Smith, Hyo-Jong Lee, Ho Young Lee   +8 more
semanticscholar   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T., Baillie, G.S., Canton, D.A., Day, J.P., Gelman, I.H., Grimes, Q., Guercio, L.A., Havekes, R., Huang, T., Luczak, V., Nie, T., Park, A.J., Scott, J.D.   +12 more
core   +2 more sources

Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.

Journal of Biological Chemistry, 1980
Incubation of C6 glioma cells with isoproterenol elicits an increase in cyclic AMP content, followed by an activation of cyclic AMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The cytoplasm of these glioma cells contains type II protein kinase and a small amount of cyclic AMP-independent protein kinase.
Joan P. Schwartz, E. Costa
openalex   +4 more sources