Results 41 to 50 of about 913,637 (282)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A beta-Poisson model for infectious disease transmission.

PLoS Computational Biology
Outbreaks of emerging and zoonotic infections represent a substantial threat to human health and well-being. These outbreaks tend to be characterised by highly stochastic transmission dynamics with intense variation in transmission potential between ...
Joe Hilton, Ian Hall
doaj   +1 more source

IDENTIFIKASI DISTRIBUSI JUMLAH KECELAKAAN LALU LINTAS DI DEPOK DAN PENDUGAAN PARAMETERNYA MENGGUNAKAN METODE BAYES

Jurnal Matematika UNAND, 2019
Kecelakaan lalu lintas adalah masalah yang umum terjadi dalam penyelenggaraan sistem transportasi. Menurut data dari Polresta Depok, diperoleh informasi bahwa jumlah kecelakaan lalu lintas mengalami penurunan di tahun 2018.
Tari Adriana Musana, FERRA YANUAR, YUDIANTRI ASDI   +2 more
doaj   +1 more source

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl, Marika C. Möller, Lindsay Wilson, Anne Vik, Toril Skandsen, Jonas Stenberg, CENTER‐TBI participants and investigators   +6 more
wiley   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Bayesian Inference For The Beta-Binomial Distribution Via Polynomial Expansions

, 2002
A commonly used paradigm in modeling count data is to assume that individual counts are generated from a Binomial distribution, with probabilities varying between individuals according to a Beta distribution.
Bradlow, E. T., Everson, Philip J.
core   +1 more source

Incident Comorbid Diabetes and Outcomes in Multiple Sclerosis: An English Population‐Based Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the incidence of diabetes mellitus and its associations with hospitalisation and mortality in adults with multiple sclerosis (MS) and matched controls. Methods Using English primary care data from the Clinical Practice Research Datalink, linked to hospital and mortality records, we matched adults with MS with up to 10 ...
Yolanda Lau, Sedigheh Zabihi, Morghan Hartmann, Georgina Mathlin, Sube Banerjee, Ebaa Marouf, Clare Hadley, Claudia Cooper, Ruth Dobson   +8 more
wiley   +1 more source

A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model [PDF]

The Egyptian Statistical Journal, 2011
In twin studies there is a need to compare a sample of monozygotic to another independent sample of dizygotic twins with respect to the presence or absence of a specific disease or condition.
Marwa Ahmed, Mohamed Shoukri
doaj   +1 more source

Statistical Inference of the Beta Binomial Exponential 2 Distribution with Application to Environmental Data

Axioms, 2022
A new four-parameter lifetime distribution called the beta binomial exponential 2 (BBE2) distribution is proposed. Some mathematical features, including quantile function, moments, generating function and characteristic function, of the BBE2 distribution,
Osama H. Mahmoud Hassan, Ibrahim Elbatal, Abdullah H. Al-Nefaie, Ahmed R. El-Saeed   +3 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source