Results 81 to 90 of about 913,637 (282)

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

Gaussian Copula Regression in R

Journal of Statistical Software, 2017
This article describes the R package gcmr for fitting Gaussian copula marginal regression models. The Gaussian copula provides a mathematically convenient framework to handle various forms of dependence in regression models arising, for example, in time ...
Guido Masarotto, Cristiano Varin
doaj   +1 more source

Epigenetic Activation of ANGPTL4 Drives EBV‐Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5

Advanced Science, EarlyView.
ANGPTL4 exhibits distinct promoter methylation patterns and expression profiles in EBV‐positive versus EBV‐negative gastric cancer. Secreted C‐terminal ANGPTL4 (cANGPTL4) acts as the dominant functional isoform driving GC proliferation, EMT, and neutrophil infiltration. cANGPTL4 promotes neutrophil recruitment via NF‐κB/CXCL8 axis.
Dandan Li, Xinqi Li, Xiangyin Luo, Jiayi Wang, Yiwei Zha, Zeng Zhou, Yanyan Chen, Qi Wang, Lingyun Xia, Weidong Leng, Shanshan Qin   +10 more
wiley   +1 more source

How Can We Analyze Differentially-Private Synthetic Datasets?

The Journal of Privacy and Confidentiality, 2011
Synthetic datasets generated within the multiple imputation framework are now commonly used by statistical agencies to protect the confidentiality of their respondents.
Anne-Sophie Charest
doaj   +1 more source

Voluntary Collective Action to Address Growing Agricultural Challenges in Two Countries: Experimental Insights and Commonalities

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We conducted two framed field economic experiments with citrus farmers in Florida, United States and soybean farmers in Argentina to investigate their willingness to coordinate pest and weed management efforts. Despite the contrast between these two agricultural contexts, we find striking behavioral commonalities.
Ariel Singerman, Sergio H. Lence
wiley   +1 more source

Incentive Payment Programs for Environmental Protection: A Framework for Eliciting and Estimating Landowners' Willingness to Participate [PDF]

This paper considers the role of incentive payment programs in eliciting, estimating, and predicting landowners’ conservation enrollments. Using both program participation and the amount of land enrolled, we develop two econometric approaches for ...
Siikamäki, Juha, Layton, David
core  

Differential p-values for Negative Binomial vs. Beta-Binomial Dispersion Methods.

, 2016
Each panel reflects a comparison of p-values for beta binomial-based dispersion or negative binomial-based dispersion generated from the UMI count data, CTRL vs SOR (A-C), or the Gierlinski data, WT vs ∆snf2 (D-F).
Gregory R. Smith (3165048), Marc R. Birtwistle (141764)   +1 more
core   +1 more source

Livelihood Diversification as an Adaptation Strategy to Climate Change and Household Food Security of Livestock Holders in Pakistan

Agribusiness, EarlyView.
ABSTRACT Rural farm households continue to face significant risks from climate change, resulting in many of them diversifying their livelihood sources into other income‐generating activities to increase their incomes and improve food and nutrition security. In this study, we examine the drivers and impact of farm households' participation in livelihood
Mahwish Arshad, Awudu Abdulai
wiley   +1 more source