Results 71 to 80 of about 83,989 (289)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Tusnady's inequality revisited

, 2004
Tusnady's inequality is the key ingredient in the KMT/Hungarian coupling of the empirical distribution function with a Brownian bridge. We present an elementary proof of a result that sharpens the Tusnady inequality, modulo constants. Our method uses the
Carter, Andrew, Pollard, David
core   +1 more source

General state-space population dynamics model for Bayesian stock assessment [PDF]

, 2015
201
Blomstedt, Paul A., Kuikka, O. Sakari, Kuparinen, Anna K., Mäntyniemi, Samu H. P., Perälä, Tommi A., Pulkkinen, Henni P., Rincon, Margarita Maria, Vanhatalo, Jarno P., Whitlock, Rebecca E.   +8 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Limit Distributions for the Estimates of the Digamma Distribution Parameters Constructed from a Random Size Sample

Mathematics, 2023
In this paper, we study a new type of distribution that generalizes distributions from the gamma and beta classes that are widely used in applications.
Alexey Kudryavtsev, Oleg Shestakov
doaj   +1 more source

Correlation Structures of Correlated Binomial Models and Implied Default Distribution

, 2008
We show how to analyze and interpret the correlation structures, the conditional expectation values and correlation coefficients of exchangeable Bernoulli random variables.
Aleksiejuk A., Andersen L., Bouchaud J.-P., Chmiel A. M., Davis M., Finger C. C., Helbing D., Hisakado M., Hull J., Iori G., Jobst N. J., Kitsukawa K., Mantegna R. A., Sakata A., Schönbucher P. J., Souma W., Vacca L.   +16 more
core   +1 more source

On choosing mixture components via non-local priors [PDF]

, 2019
Choosing the number of mixture components remains an elusive challenge. Model selection criteria can be either overly liberal or conservative and return poorly-separated components of limited practical use.
Fúquene, Jairo, Rossell, David, Steel, Mark   +2 more
core   +2 more sources

Hip Morphology–Based Osteoarthritis Risk Prediction Models: Development and External Validation Using Individual Participant Data From the World COACH Consortium

Arthritis Care &Research, EarlyView.
Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Jinchi Tang, Harbeer Ahedi, Nigel K. Arden, Sita M. A. Bierma‐Zeinstra, Cindy G. Boer, Flavia M. Cicuttini, Timothy F. Cootes, David T. Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E. Lane, Claudia Lindner, Joyce B. J. van Meurs, Andrea Mosler, Amanda E. Nelson, Michael C. Nevitt, Edwin H. Oei, Jos Runhaar, Harrie Weinans, Jesse H. Krijthe, Rintje Agricola   +26 more
wiley   +1 more source

bayesint: A Python Package for Calculating Bayesian Credible Intervals of Ratios of Beta Distributions

Journal of Open Research Software, 2021
We present 'bayesint', a Python package for calculating Bayesian credible intervals for ratios of two independent beta distributions such as are used when considering binomial data. Such data could be found in counts of events in medical diagnostic tests,
M. Bekker-Nielsen Dunbar, Thomas J. R. Finnie   +1 more
doaj   +1 more source