Results 61 to 70 of about 5,240,370 (291)
Advanced Science, EarlyView.Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu +15 more
wiley +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
, 2023 Effect on β-binomial mass function for different values of ν fixing α = 7.15 and β = 28.62. (PNG)
François-Xavier Dupé (17364494) +3 more
core +1 more source
Advanced Science, EarlyView.Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan +13 more
wiley +1 more source
Sum of Bernoulli Mixtures: Beyond Conditional Independence
Journal of Probability and Statistics, 2014 We consider the distribution of the sum of Bernoulli mixtures under a general dependence structure. The level of dependence is measured in terms of a limiting conditional correlation between two of the Bernoulli random variables.
Taehan Bae, Ian Iscoe
doaj +1 more source
Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
Austrian Journal of Statistics, 2018 This paper deals with the estimation procedure for inverse Weibull distribution under progressive type-II censored samples when removals follow Beta-binomial probability law. To estimate the unknown parameters, the maximum likelihood and Bayes estimators
Pradeep Kumar Vishwakarma +4 more
doaj +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Revista Colombiana de Estadística, 2009 En el modelamiento de datos donde se evidencia la presencia de sobredispersión, usualmente se asume que para todos los efectos de tratamiento el parámetro de sobredispersión es común.
MARIO ALFONSO MORALES +1 more
doaj
Derivatives of the Incomplete Beta Function [PDF]
The incomplete beta function is defined as where Beta(p, q) is the beta function. Dutka (1981) gave a history of the development and numerical evaluation of this function. In this article, an algorithm for computing first and second derivatives of Ix,p,q
James F. Robinson-Cox, Robert J. Boik
core