Results 61 to 70 of about 5,487,097 (292)

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

open access: yesAdvanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang   +5 more
wiley   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

open access: yesAdvanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang   +16 more
wiley   +1 more source

Empirical-distribution-function tests for the beta-binomial model

open access: yes, 2010
碩士本文主要是探討應用經驗分布函數對貝他-二項式模式做適合度檢定. 我們提出兩種以經驗分布函數為基礎之統計量的檢定方法, 然後透過蒙地卡羅模擬研究去檢定統計量在對立假設下之不同分布的經驗檢定力. 與 Garren et al. (2001) 的方法相比較, 我們的方法在大多數的情況下是具有較大檢定力的.
周正杰; Chou, Cheng-chieh
core   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

open access: yesAdvanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan   +5 more
wiley   +1 more source

Sum of Bernoulli Mixtures: Beyond Conditional Independence

open access: yesJournal of Probability and Statistics, 2014
We consider the distribution of the sum of Bernoulli mixtures under a general dependence structure. The level of dependence is measured in terms of a limiting conditional correlation between two of the Bernoulli random variables.
Taehan Bae, Ian Iscoe
doaj   +1 more source

Bayesian Estimation for Inverse Weibull Distribution Under Progressive Type-II Censored Data With Beta-Binomial Removals

open access: yesAustrian Journal of Statistics, 2018
This paper deals with the estimation procedure for inverse Weibull distribution under progressive type-II censored samples when removals follow Beta-binomial probability law. To estimate the unknown parameters, the maximum likelihood and Bayes estimators
Pradeep Kumar Vishwakarma   +4 more
doaj   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

open access: yesAdvanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou   +10 more
wiley   +1 more source

Estudio de homogeneidad de la dispersión en diseño a una vía de clasificación para datos de proporciones y conteos

open access: yesRevista Colombiana de Estadística, 2009
En el modelamiento de datos donde se evidencia la presencia de sobredispersión, usualmente se asume que para todos los efectos de tratamiento el parámetro de sobredispersión es común.
MARIO ALFONSO MORALES   +1 more
doaj  

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

open access: yesAdvanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang   +15 more
wiley   +1 more source

Derivatives of the Incomplete Beta Function [PDF]

open access: yes
The incomplete beta function is defined as where Beta(p, q) is the beta function. Dutka (1981) gave a history of the development and numerical evaluation of this function. In this article, an algorithm for computing first and second derivatives of Ix,p,q
James F. Robinson-Cox, Robert J. Boik
core  

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