Results 51 to 60 of about 5,240,370 (291)

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

bayesint: A Python Package for Calculating Bayesian Credible Intervals of Ratios of Beta Distributions

Journal of Open Research Software, 2021
We present 'bayesint', a Python package for calculating Bayesian credible intervals for ratios of two independent beta distributions such as are used when considering binomial data. Such data could be found in counts of events in medical diagnostic tests,
M. Bekker-Nielsen Dunbar, Thomas J. R. Finnie   +1 more
doaj   +1 more source

The beta-binomial distribution for estimating the number of false rejections in microarray gene expression studies [PDF]

Computational Statistics & Data Analysis, 2009
In differential expression analysis of microarray data, it is common to assume independence among null hypotheses (and thus gene expression levels). The independence assumption implies that the number of false rejections V follows a binomial distribution and leads to an estimator of the empirical false discovery rate (eFDR).
Daniel Hunt, Cheng Cheng, Stanley Pounds
openaire   +3 more sources

Estimação dos parâmetros da distribuição beta-binomial [PDF]

, 2015
Neste artigo nós descrevemos a estimação dos parâmetros da distribuição beta-binomial usando o procedimento NLMIXED do software SAS. A distribuição beta-binomial é uma distribuição de misturas discreta capaz de capturar a superdispersão dos dados.
Aragon, Davi Casale, Achcar, Jorge Alberto, Martinez, Edson Zangiacomi   +2 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Empirical-distribution-function tests for the beta-binomial model

, 2010
碩士本文主要是探討應用經驗分布函數對貝他-二項式模式做適合度檢定. 我們提出兩種以經驗分布函數為基礎之統計量的檢定方法, 然後透過蒙地卡羅模擬研究去檢定統計量在對立假設下之不同分布的經驗檢定力. 與 Garren et al. (2001) 的方法相比較, 我們的方法在大多數的情況下是具有較大檢定力的.
周正杰; Chou, Cheng-chieh
core   +1 more source

Circular Polya distributions of order k

International Journal of Mathematics and Mathematical Sciences, 2003
Two circular Polya distributions of order k are derived by means of generalized urn models and by compounding, respectively, the type I and type II circular binomial distributions of order k of Makri and Philippou (1994) with the beta distribution. It is
Gregory A. Tripsiannis, Andreas N. Philippou   +1 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Modelling Coronavirus and Larvae Pyrausta Data: A Discrete Binomial Exponential II Distribution with Properties, Classical and Bayesian Estimation

Axioms, 2022
In this article, we propose the discrete version of the binomial exponential II distribution for modelling count data. Some of its statistical properties including hazard rate function, mode, moments, skewness, kurtosis, and index of dispersion are ...
Mohamed S. Eliwa, Abhishek Tyagi, Bader Almohaimeed, Mahmoud El-Morshedy   +3 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source