Results 41 to 50 of about 84,615 (280)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Limit Distributions for the Estimates of the Digamma Distribution Parameters Constructed from a Random Size Sample

Mathematics, 2023
In this paper, we study a new type of distribution that generalizes distributions from the gamma and beta classes that are widely used in applications.
Alexey Kudryavtsev, Oleg Shestakov
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

bayesint: A Python Package for Calculating Bayesian Credible Intervals of Ratios of Beta Distributions

Journal of Open Research Software, 2021
We present 'bayesint', a Python package for calculating Bayesian credible intervals for ratios of two independent beta distributions such as are used when considering binomial data. Such data could be found in counts of events in medical diagnostic tests,
M. Bekker-Nielsen Dunbar, Thomas J. R. Finnie   +1 more
doaj   +1 more source

Optimal stopping times for estimating Bernoulli parameters with applications to active imaging [PDF]

, 2018
We address the problem of estimating the parameter of a Bernoulli process. This arises in many applications, including photon-efficient active imaging where each illumination period is regarded as a single Bernoulli trial. We introduce a framework within
Goyal, Vivek K., Medin, Safa C., Murray-Bruce, John   +2 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Measurement of the scintillation time spectra and pulse-shape discrimination of low-energy beta and nuclear recoils in liquid argon with DEAP-1 [PDF]

, 2016
The DEAP-1 low-background liquid argon detector was used to measure scintillation pulse shapes of electron and nuclear recoil events and to demonstrate the feasibility of pulse-shape discrimination (PSD) down to an electron-equivalent energy of 20 keV.
A. Butcher, A. Muir, A.B. McDonald, A.J. Noble, A.L. Hallin, Acciarri, Acciarri, Acosta-Kane, Agnes, Agnes, Agostinelli, Akashi-Ronquest, Akerib, Amaudruz, Amole, Angle, B. Beltran, B. Broerman, B. Cai, B. Smith, B.T. Cleveland, Benetti, Benetti, Boulay, Boulay, Bromiley, Brun, Burton, C. Hearns, C. Nantais, C. Ouellet, C.J. Jillings, Caldwell, Cao, Cowan, Creus, D. Cranshaw, D.N. McKinsey, D.R. Grant, Doke, E. Grace, E. O’Dwyer, E. Vázquez-Jáuregui, F. Duncan, F. Giuliani, F. La Zia, F. Retière, Gastler, Gedanken, Hinkley, Hitachi, I. Lawson, J. Bonatt, J. Hofgartner, J. Monroe, J. Nikkel, J. Tang, J. Walding, J.F. Bueno, J.J. Lidgard, Jillings, K. Boudjemline, K. Dering, K. Graham, K. McFarlane, K. Nicolics, K. Olsen, Keith, L. Veloce, Lewin, Lidgard, Lippincott, Loosli, M. Batygov, M. Chen, M. Gold, M. Hamstra, M. Kuźniak, M. Ronquest, M. Ward, M.G. Boulay, Miyajima, Mulliken, N. Fatemighomi, N. Seeburn, O. Li, O’Dwyer, P. Giampa, P. Gorel, P. Harvey, P. Liimatainen, P. Pasuthip, P. Skensved, P.-A. Amaudruz, Pasuthup, R. Chouinard, R. Ford, R. Gagnon, R. Hakobyan, R. Mathew, R. Mehdiyev, Regenfus, Rubbia, S.J.M. Peeters, Suemoto, Szydagis, T. Caldwell, T. McElroy, T. Pollmann, T. Sonley, V.V. Golovko, W. Rau, W.H. Lippincott, Xiao   +113 more
core   +2 more sources

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Modelling Coronavirus and Larvae Pyrausta Data: A Discrete Binomial Exponential II Distribution with Properties, Classical and Bayesian Estimation

Axioms, 2022
In this article, we propose the discrete version of the binomial exponential II distribution for modelling count data. Some of its statistical properties including hazard rate function, mode, moments, skewness, kurtosis, and index of dispersion are ...
Mohamed S. Eliwa, Abhishek Tyagi, Bader Almohaimeed, Mahmoud El-Morshedy   +3 more
doaj   +1 more source