Results 151 to 160 of about 1,020,842 (327)

Evaluation of Induced Pluripotent Stem Cell‐Derived Dopaminergic Neurons from Siblings with Gaucher Disease Discordant for Parkinsonism

open access: yesMovement Disorders, EarlyView.
Abstract Background In Gaucher disease (GD), glucocerebrosidase (GCase) deficiency results from biallelic pathogenic GBA1 variants. While GBA1 variants are a major risk factor for Parkinson's disease (PD), most patients with GD never develop parkinsonism.
Ellen Hertz   +12 more
wiley   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca   +3 more
wiley   +1 more source

Bacterial Biosensors for Measuring Availability of Environmental Pollutants

open access: yesSensors, 2008
Traditionally, pollution risk assessment is based on the measurement of a pollutant’s total concentration in a sample. The toxicity of a given pollutant in the environment, however, is tightly linked to its bioavailability, which may differ ...
Jan Roelof van der Meer, Robin Tecon
doaj  

Tethered Catalytic Hairpin Assembly with Plasmon‐Enhanced Fluorescence Readout for Single Molecule Detection

open access: yesSmall Methods, EarlyView.
This work presents a single‐molecule detection platform that does not rely on the partitioning of analyzed liquid samples and on enzymatic amplification of fluorescence signals. A flexible polymer linker serves to spatially confine catalytic‐harpin assembly‐based DNA amplification.
Naoto Asai   +6 more
wiley   +1 more source

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

open access: yesVIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang   +10 more
wiley   +1 more source

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