Results 131 to 140 of about 76,944 (297)

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

open access: yesAdvanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru   +6 more
wiley   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang   +5 more
wiley   +1 more source

A study on enzyme activities of some sphingolipidoses

open access: yesThe Turkish Journal of Pediatrics, 1994
Enzyme activities were determined in fibroblast cell cultures of eight patients suspected of having a type of sphingolipidosis. The patients were 0 to 4 years of age; four were female and four were male.
H A Ozkara   +4 more
doaj  

Mudanças relacionadas ao amaciamento da graviola durante a maturação pós-colheita. [PDF]

open access: yes, 2018
Este trabalho teve por objetivo avaliar mudanças físicas, químicas e bioquímicas relacionadas ao amaciamento de graviola (Annona muricata L.) Crioula durante a maturação.
ALVES, R. E.   +2 more
core  

When should we think about Fabry disease?

open access: yesJournal of Education, Health and Sport
According to the European Union definition, a rare disease is a disease that occurs with a frequency of less than 5 per 10,000. Rare diseases pose a major diagnostic problem for physicians.
Natalia Chojnacka   +7 more
doaj   +1 more source

Effects of Mutating CtrA-Binding Sites within the pile Promoter of Caulobacter Crescentus [PDF]

open access: yes, 2017
This project investigated the regulation of pilA by the global transcriptional regulator CtrA in the dimorphic bacterium Caulobacter crescentus. The pilA gene encodes the pilin subunits which are polymerized into helical filaments to produce pili, and ...
Chong, Sarah
core   +1 more source

Common lines ab-initio reconstruction of $D_2$-symmetric molecules

open access: yes, 2019
Cryo-electron microscopy is a state-of-the-art method for determining high-resolution three-dimensional models of molecules, from their two-dimensional projection images taken by an electron microscope. A crucial step in this method is to determine a low-
Rosen, Eitan, Shkolnisky, Yoel
core  

Differences in SARS‐CoV‐2 Antigen Persistence in Individuals With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A RECOVER‐Adult Cohort Study

open access: yesArthritis &Rheumatology, EarlyView.
Objective Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post–acute COVID‐19 outcomes, though whether individuals with SARDs have longer persistence of viral antigens after COVID‐19 has not been studied.
Naomi J. Patel   +18 more
wiley   +1 more source

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