Results 121 to 130 of about 871,979 (295)

Convenient synthesis of beta-galactosyl nucleosides using the marine beta-galactosidase from Aplysia fasciata

, 2007
A convenient synthesis of beta-galactosyl derivatives of antiviral and anticancer nucleosides, which utilizes the purified beta-galactosidase activity from the hapatopancreas of Aplysia fasciata, is reported.
Andreotti G, Giordano A, Trincone A
core   +1 more source

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

A signal sequence is not sufficient to lead beta-galactosidase out of the cytoplasm

, 1980
Escherichia coli strains have been constructed in which lacZ, the gene for the cytoplasmic enzyme beta-galactosidase, is fused to lamB, the gene for an outer membrane protein.
Silhavy, T. J., Moreno, F., Zabin, I., Hall, M., Fowler, A. V., Schwartz, M.   +5 more
core  

One-step separation of beta-galactosidase from beta-lactoglobulin using water-in-oil microemulsions

, 2012
Solubilisation of beta-galactosidase from Kluyveromyces lactis in Aerosol-OT water-in-isooctane microemulsions was measured as a function of buffer type and concentration, pH, and protein concentration.
Hamamcı, Haluk, HAMAMCI, HALUK, Dungan, Stephanie R., Mazi, Bekir G.   +3 more
core   +1 more source

Differential Diagnosis of Mucopolysaccharidoses Types I, II, III, IVA, and VI Through Analysis of Leukocytic Inclusions

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs), which can lead to cytoplasmic alterations in leukocytes. The objective of this study was to characterize leukocyte inclusions in patients with different types of MPS and assess their diagnostic relevance.
Márcio A. W. Melo, Marcelo S. Kertenetzky, Cristina M. Silveira, Maíra M. Ribeiro, Paula F. Medeiros, Gabriela S. Arcanjo   +5 more
wiley   +1 more source

Immobilization of β-galactosidase on Novel Polymers Having Schiff Bases

, 2011
We have developed a strategy to immobilize beta-galactosidase as a model enzyme by using polymeric supports having Schiff bases, which were prepared from (aminomethyl) polystyrene and 2-phenlyindole-3-carboxaldehyde by condensation.
Aynaci, Elif, SARI, NURŞEN, Hayrettin Tümtürk, Nurşen Sarı, Elif Aynacı, TÜMTÜRK, HAYRETTİN   +5 more
core   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Development of a gene-editing strategy to overcome genetic intractability in Lactobacillus johnsonii

Journal of Bacteriology
Genetic editing in lactobacilli is often constrained by their robust defense mechanisms against foreign DNA and low transformation efficiency, resulting in pronounced species- and strain-specific variability in the performance of genetic tools.
Keerthikka Ravi, Nicole R. Falkowski, Gary B. Huffnagle   +2 more
doaj   +1 more source

When should we think about Fabry disease?

Journal of Education, Health and Sport
According to the European Union definition, a rare disease is a disease that occurs with a frequency of less than 5 per 10,000. Rare diseases pose a major diagnostic problem for physicians.
Natalia Chojnacka, Radosław Cymer, Karolina Jurasz, Dominika Podgórska, Ewa Rzeska, Miłosz Sanecki, Karolina Tomczyk, Jakub Klarycki   +7 more
doaj   +1 more source

Whole-mount Senescence-Associated Beta-Galactosidase (SA-β-GAL) Activity Detection Protocol for Adult Zebrafish.

Bio Protoc, 2022
Marzullo M, El Maï M, Ferreira MG.
europepmc   +1 more source