Results 111 to 120 of about 76,944 (297)

Potential Effects of Selected Synthetic Cannabinoids on Neuronal Senescence: Impact on Proliferation and Beta-Galactosidase Activity in SH-SY5Y Cells

Emerging Trends in Drugs, Addictions, and Health
Introduction: Synthetic cannabinoids (SC) display a pharmacological mechanism similar to that of Δ9-tetrahydrocannabinol (THC), the key active principle of cannabis.
R. Roque-Bravo, H. Carmo, J. Pedro Silva, F. Carvalho, D. Dias da Silva   +4 more
doaj   +1 more source

Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation. [PDF]

RSC Adv, 2022
Lee SK, Shen Z, Han MS, Tung CH.
europepmc   +1 more source

Studies on .BETA.-galactosidase. I. Purification and properties of .BETA.-galactosidase I and II from Sclerotium tuliparum.

Chemical and Pharmaceutical Bulletin, 1976
Acid β-galactosidase I and II (β-D-galactoside galactohydrolase, EC 3. 2. 1. 23) from Sclerotium tuliparum were purified by column chromatography with DEAE-cellulose, SP-Sephadex C-50, Sephadex G-200 and by isoelectric focusing (pI, 4.5 and 4.4, respectively). The purified β-galactosidase I and II were homogeneous in disc electrophoresis.
SUGIURA, MAMORU, SUZUKI, MUTSUKO, SASAKI, MASANORI, SHIMOMURA, TOKIKO   +3 more
openaire   +3 more sources

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Valuation of agro-industrial wastes as substrates for heterologous production of α-galactosidase

Microbial Cell Factories, 2018
Background The recycling of agro-industrial wastes is at present limited by the availability of efficient and low-cost enzyme cocktails. The use of these materials as culture media to produce the enzymes can contribute to the profitability of the ...
María-Efigenia Álvarez-Cao, Agustín Rico-Díaz, María-Esperanza Cerdán, Manuel Becerra, María-Isabel González-Siso   +4 more
doaj   +1 more source

Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold. [PDF]

Sci Rep, 2021
Katoh S, Fujimaru A, Iwasaki M, Yoshioka H, Senthilkumar R, Preethy S, Abraham SJK.   +6 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +2 more sources

Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts. [PDF]

Biomed Res Int, 2021
Boulfia M, Lamchouri F, Toufik H.
europepmc   +1 more source