Results 111 to 120 of about 76,419 (299)

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

open access: yes, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle   +9 more
core   +2 more sources

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang   +5 more
wiley   +1 more source

Potential Effects of Selected Synthetic Cannabinoids on Neuronal Senescence: Impact on Proliferation and Beta-Galactosidase Activity in SH-SY5Y Cells

open access: yesEmerging Trends in Drugs, Addictions, and Health
Introduction: Synthetic cannabinoids (SC) display a pharmacological mechanism similar to that of Δ9-tetrahydrocannabinol (THC), the key active principle of cannabis.
R. Roque-Bravo   +4 more
doaj   +1 more source

Valuation of agro-industrial wastes as substrates for heterologous production of α-galactosidase

open access: yesMicrobial Cell Factories, 2018
Background The recycling of agro-industrial wastes is at present limited by the availability of efficient and low-cost enzyme cocktails. The use of these materials as culture media to produce the enzymes can contribute to the profitability of the ...
María-Efigenia Álvarez-Cao   +4 more
doaj   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

open access: yesAnimal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang   +8 more
wiley   +1 more source

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