Results 91 to 100 of about 76,944 (297)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study

Clinical Interventions in Aging, 2012
Salvatore Rinaldi,1,2 Margherita Maioli,1,3,4 Sara Santaniello,3,4 Alessandro Castagna,1,2 Gianfranco Pigliaru,3,4 Sara Gualini,3,4 Matteo Lotti Margotti,5 Arturo Carta,6 Vania Fontani,1,2 Carlo Ventura1,4,71Department of Regenerative Medicine, Rinaldi ...
Rinaldi S, Maioli M, Santaniello S, Castagna A, Pigliaru GF, Gualini S, Margotti ML, Carta A, Fontani V, Ventura C   +9 more
doaj  

Regulation of tomato fruit ripening [PDF]

, 2009
Fruit ripening is a sophisticatedly orchestrated developmental process, unique to plants, that results in major physiological and metabolic changes, ultimately leading to fruit decay and seed dispersal.
Bouzayen, Mondher, Latché, Alain, Pech, Jean-Claude, Pirrello, Julien, Regad, Farid   +4 more
core   +2 more sources

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Galacto-Oligosaccharides : production, properties, applications, and significance as prebiotics [PDF]

, 2010
Galacto-oligosaccharides (GOS) have now been definitely established as prebiotic ingredients after in vitro and animal and human in vivo studies. Currently, GOS are produced by glycoside hydrolases (GH) using lactose as substrate.
[AOAC] Assn. of Official Analytical Chemists, [AOAC]Assn. of Official Analytical Chemists, Adam, Akiyama, Albayrak, Albayrak, Albayrak, Alles, Aronson, Aslan, Asp, Backhed, Bakker-Zierikzee, Ballio, Biggs, Bockmühl, Boehm, Boehm, Boon, Boon, Boon, Boon, Bouhnik, Bruins, Burr, Burvall, Cantarel, Cardelle-Cobas, Chen, Chen, Cheng, Cheng, Cheng, Cho, Chockchaisawasdee, Choi, Chonan, Coulier, Coutinho, Crittenden, Crout, Cruz, Cummings, Cummings, Czermak, Davies, De Roode, De Slegte, Del-Val, Del-Val, Depeint, DeVries, Drueckhammer, Dumortier, Ebrahimi, Ebrahimi, Engel, European Directive, European Regulation, Fanaro, Fanaro, Fanaro, Feng, Foda, Fox, Ganzle, Gaur, Gekas, Gibson, Gibson, Gibson, Gill, Gorin, Gorin, Goulas, Goulas, Goulas, Goulas, Greenberg, Grisdale-Helland, Hansson, Hansson, Harmsen, Hartemink, Henrissat, Henrissat, Hernandez, Houdijk, Houdijk, Hsu, Huber, Huh, Huh, Hung, Hung, Iqbal, Ishikawa, Ito, Ito, Iwasaki, Jeon, Ji, Jorgensen, Jung, Jung, Kim, Kim, Knol, Knol, Koshland, Krutmann, Kunz, Lairson, Leiva, Li, Li, Lifran, Lu, Lu, Lupp, Ly, Macfarlane, Macfarlane, Maischberger, Martinez-Villaluenga, Matella, Maugard, McCartney, Modesto, Moller, Monsan, Montanes, Moro, Mozaffar, Mozaffar, Mozaffar, Mwenya, Mwenya, Nakao, Nakayama, Nakkharat, Nakkharat, Neri, Neri, Newburg, Nguyen, Nobre, Ohtsuka, Ohtsuka, Onishi, Onishi, Onishi, Onishi, Onishi, Onishi, Paige, Panesar, Park, Paterson, Pazur, Pazur, Petzelbauer, Petzelbauer, Petzelbauer, Pivarnik, Placier, Playne, Prakash, Prakash, Prapulla, Prenosil, Rabiu, Rastall, Rehman, Richmond, Roberfroid, Roberfroid, Roberts, Roos, Ross, Rowland, Roy, Rustom, Sakai, Sako, Santoso, Sar, Schaafsma, Sekirov, Sheu, Shin, Shin, Silk, Sinclair, Sinnott, Splechtna, Splechtna, Splechtna, Stevenson, Tanaka, Toba, Toba, Toba, Tzortzis, Tzortzis, Tzortzis, Tzortzis, Van Loo, Vulevic, Wallenfels, Wallenfels, Widmer, Wikoff, Yanahira, Yang, Yang, Zechel, Zhou   +217 more
core   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Study of the transgalactosylation activity of ß-galactosidase from a new strain Kluyveromyces lactis 3 [PDF]

Journal of BioScience and Biotechnology, 2012
Beta-galactosidase (EC.3.2.1.23) is an important enzyme industrially used for the hydrolysis of lactose from milk and milk whey for several applications.
ILIA ILIEV, TONKA VASILEVA
doaj  

Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. [PDF]

, 2020
Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27
Chopra, Deeksha G, Hennings, Thomas G, Ku, Gregory M, Yiv, Nicholas, Zhang, Yaohuan   +4 more
core