Results 71 to 80 of about 76,419 (299)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes. [PDF]

, 1983
We located the polypeptide nascent chain as it leaves cytoplasmic ribosomes from the plant Lemna gibba by immune electron microscopy using antibodies against the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase.
Bernabeu, C, Fowler, A, Lake, JA, Tobin, EM, Zabin, I   +4 more
core  

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, EarlyView.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Reference values for lysosomal enzymes activities using dried blood spots samples - a Brazilian experience

Diagnostic Pathology, 2010
Background Lysosomal storage diseases (LSD) are inherited disorders caused by deficiency of lysosomal enzymes in which early diagnosis is essential to provide timely treatment. This study reports interval values for the activity of lysosomal enzymes that
Martins Ana M, Pereira Vanessa G, Rodrigues Mayra DB, Müller Karen B, D'Almeida Vânia   +4 more
doaj   +1 more source

Galacto-Oligosaccharides : production, properties, applications, and significance as prebiotics [PDF]

, 2010
Galacto-oligosaccharides (GOS) have now been definitely established as prebiotic ingredients after in vitro and animal and human in vivo studies. Currently, GOS are produced by glycoside hydrolases (GH) using lactose as substrate.
[AOAC] Assn. of Official Analytical Chemists, [AOAC]Assn. of Official Analytical Chemists, Adam, Akiyama, Albayrak, Albayrak, Albayrak, Alles, Aronson, Aslan, Asp, Backhed, Bakker-Zierikzee, Ballio, Biggs, Bockmühl, Boehm, Boehm, Boon, Boon, Boon, Boon, Bouhnik, Bruins, Burr, Burvall, Cantarel, Cardelle-Cobas, Chen, Chen, Cheng, Cheng, Cheng, Cho, Chockchaisawasdee, Choi, Chonan, Coulier, Coutinho, Crittenden, Crout, Cruz, Cummings, Cummings, Czermak, Davies, De Roode, De Slegte, Del-Val, Del-Val, Depeint, DeVries, Drueckhammer, Dumortier, Ebrahimi, Ebrahimi, Engel, European Directive, European Regulation, Fanaro, Fanaro, Fanaro, Feng, Foda, Fox, Ganzle, Gaur, Gekas, Gibson, Gibson, Gibson, Gill, Gorin, Gorin, Goulas, Goulas, Goulas, Goulas, Greenberg, Grisdale-Helland, Hansson, Hansson, Harmsen, Hartemink, Henrissat, Henrissat, Hernandez, Houdijk, Houdijk, Hsu, Huber, Huh, Huh, Hung, Hung, Iqbal, Ishikawa, Ito, Ito, Iwasaki, Jeon, Ji, Jorgensen, Jung, Jung, Kim, Kim, Knol, Knol, Koshland, Krutmann, Kunz, Lairson, Leiva, Li, Li, Lifran, Lu, Lu, Lupp, Ly, Macfarlane, Macfarlane, Maischberger, Martinez-Villaluenga, Matella, Maugard, McCartney, Modesto, Moller, Monsan, Montanes, Moro, Mozaffar, Mozaffar, Mozaffar, Mwenya, Mwenya, Nakao, Nakayama, Nakkharat, Nakkharat, Neri, Neri, Newburg, Nguyen, Nobre, Ohtsuka, Ohtsuka, Onishi, Onishi, Onishi, Onishi, Onishi, Onishi, Paige, Panesar, Park, Paterson, Pazur, Pazur, Petzelbauer, Petzelbauer, Petzelbauer, Pivarnik, Placier, Playne, Prakash, Prakash, Prapulla, Prenosil, Rabiu, Rastall, Rehman, Richmond, Roberfroid, Roberfroid, Roberts, Roos, Ross, Rowland, Roy, Rustom, Sakai, Sako, Santoso, Sar, Schaafsma, Sekirov, Sheu, Shin, Shin, Silk, Sinclair, Sinnott, Splechtna, Splechtna, Splechtna, Stevenson, Tanaka, Toba, Toba, Toba, Tzortzis, Tzortzis, Tzortzis, Tzortzis, Van Loo, Vulevic, Wallenfels, Wallenfels, Widmer, Wikoff, Yanahira, Yang, Yang, Zechel, Zhou   +217 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Nanozymes as Enzyme Inhibitors

International Journal of Nanomedicine, 2021
Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key ...
Huang Y, Jiang J, Wang Y, Chen J, Xi J
doaj  

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Determination of optimal conditions of action of beta-galactosidases of producers with different properties

Современная наука и инновации
The synthesis of beta-galactosidase is observed in microorganisms of various taxonomic groups, including some strains of yeast fungi and lactic acid bacteria.
M. A. Shpak, S. A. Ryabtseva, A. D. Lodygin, P. I. Kornienko, P. S. Kolyadina   +4 more
doaj   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source