Results 171 to 180 of about 57,584 (261)

Nutritional quality traits in pea seed: Current knowledge and opportunities for genetic improvement

Annals of Applied Biology, Volume 189, Issue 2, September 2026.
This comprehensive review on nutritional traits in pea (Pisum sativum L.) summarizes the literature on genetic improvement of this highly nutritious and environmentally sustainable crop for different end‐uses. Abstract Pea is a major pulse crop valued for its high protein, carbohydrate, and mineral content, as well as its agronomic role in sustainable ...
Ahmed O. Warsame, Janneke Balk
wiley   +1 more source

Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment. [PDF]

Autophagy
Lu JJ, Sheng YR, Hu WT, Liu YK, Xie F, Li MQ, Zhu XY.   +6 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Immortalized Rat Tendon-Derived Stem Cells for Tendon Tissue Engineering. [PDF]

Bioengineering (Basel)
Lau KT, Wang H, Zhang J, Wang DM, Ker DFE.   +4 more
europepmc   +1 more source

Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL

Immunology, Volume 179, Issue 1, Page 149-160, September 2026.
In this study, we detect senescent endothelial cells within chronically diseased human liver tissues. Next, we develop a novel protocol for the induction of paracrine senescence in primary human liver endothelial cells and explore their functionality.
Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty   +9 more
wiley   +1 more source

Enzyme-Responsive Cyclic Gapmer Antisense Oligonucleotides via Thymidine <i>C</i>5-<i>C</i>5 Cross-Linking within the Gap Region Using a Galactosylated Branched Self-Immolative Linker. [PDF]

Bioconjug Chem
Miyaji K, Habu N, Seio K.
europepmc   +1 more source

Doxorubicin‐Induced Cytotoxicity in Adipose‐Derived Stem Cells Is Associated With Altered SAPK/JNK Signaling

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
This study investigated the effects of clinically relevant concentrations of doxorubicin (Dox; 5 μM), commonly used in anticancer therapy, on adipose‐derived stem cells (ADSCs). Dox induced ADSC dysfunction, characterized by reduced mitochondrial activity, apoptosis, oxidative stress, premature senescence, cytoskeletal alterations, and cell cycle ...
Aleksandra Skubis‐Sikora, Kinga Pogoda‐Mieszczak, Bartosz Sikora, Edyta Bogunia, Aleksandra Bryzek, Piotr Czekaj   +5 more
wiley   +1 more source

Q1020R in the spike proteins of MERS-CoV from Arabian camels confers resistance against soluble human DPP4. [PDF]

J Virol
Chen N, Kleine-Weber H, Alkharsah K, Winkler M, Volz A, Müller MA, Corman VM, Drosten C, Hoffmann M, Pöhlmann S.   +9 more
europepmc   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

Direct Competitive Kinetic Isotope Effect Measurement Using Quantitative Whole Molecule Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. [PDF]

Chembiochem
Kljaic T, Scott MA, Guirguis V, Tyrlik M, Liu A, Poulin MB.   +5 more
europepmc   +1 more source