The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]
, 2013 Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Courtial, Nadine +5 more
core +14 more sources
Drugs in R&D, 2023 Background and Objective Fabry disease (FD) is a rare lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (aGal A). Since 2001, two different enzyme replacement therapies have been authorized, with agalsidase beta being used
André B. P. van Kuilenburg +11 more
doaj +1 more source
Phylogenomic study of Burkholderia glathei-like organisms, proposal of 13 novel Burkholderia species and emended descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae [PDF]
, 2016 Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei Glade (BGC) bacteria.
Cooper, Vaughn S +5 more
core +6 more sources
Study of β-Galactosidase Enzyme Activity Produced by Lactobacilli in Milk and Cheese [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008 Background and objective Lactose intolerance is a discomfort state that occurs in some people after ingestion of milk and it is due to insufficient amount of beta galactosidase in the human gut to digest lactose.
J Nowroozi +2 more
doaj +1 more source
A novel Arthrobacter beta-galactosidase with homology to eucaryotic beta-galactosidases
Journal of Bacteriology, 1997 An Arthrobacter beta-galactosidase has homology with the lysosomal acid beta-galactosidases from humans and mice and with a Xanthomonas manihotis enzyme. Phylogenetic analysis of the deduced amino acid sequence showed an unusual pattern, with this procaryotic enzyme clustering within the animal clade.
K Wang +2 more
openaire +4 more sources
Evaluation of beta-galactosidase activity in tissue in the presence of blood [PDF]
, 2000 The reporter gene for beta -galactosidase is frequently used to determine the efficiency of gene transfer in arteries. However, blood is often present in arterial explants and may compromise the results by the presence of hemoglobin. The light absorption
Armeanu, Sorin +2 more
core +1 more source
Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro
Cells, 2022 Detection and quantification of senescent cells remain difficult due to variable phenotypes and the absence of highly specific and reliable biomarkers. It is therefore widely accepted to use a combination of multiple markers and cellular characteristics ...
Tom Zimmermann +5 more
doaj +1 more source
Aspergillus niger β-galactosidase production by yeast in a continuous high cell density reactor [PDF]
, 2005 The continuous production of extracellular heterologous beta-galactosidase by a recombinant flocculating Saccharomyces cerevisiae, expressing the lacA gene (coding for beta-galactosidase) of Aspergillus niger was investigated.
Domingues, Lucília +2 more
core +1 more source
Programmed Cell Senescence in the Mouse Developing Spinal Cord and Notochord
Frontiers in Cell and Developmental Biology, 2021 Programmed cell senescence is a cellular process that seems to contribute to embryo development, in addition to cell proliferation, migration, differentiation and programmed cell death, and has been observed in evolutionary distant organisms such as ...
Jorge Antolio Domínguez-Bautista +2 more
doaj +1 more source
Beta galactosidases in Arabidopsis and tomato–a mini review [PDF]
Biochemical Society Transactions, 2016 Beta galactosidases (BGALs) are glycosyl hydrolases that remove terminal β-D-galactosyl residues from β-D-galactosides. There are 17 predicted BGAL genes in the genomes of both Arabidopsis (BGAL1–17) and tomato (TBG1–17). All tested BGALs have BGAL activity but their distinct expression profiles and ancient phylogenetic separation indicates that these ...
Balakumaran Chandrasekar +3 more
openaire +4 more sources