Results 211 to 220 of about 1,020,842 (327)

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

PRRX2 Regulates GLI2 to Promote Proliferation, Invasion, and Metastasis by Inhibiting Senescence via Hedgehog Signaling

open access: yesCancer Science, EarlyView.
PRRX2 is highly expressed in pancreatic cancer and correlates with patient prognosis. PRRX2 promotes pancreatic cancer cell proliferation, invasion, and metastasis, and inhibits pancreatic cancer cell senescence. PRRX2 transcriptionally regulates GLI2 and activates the Hedgehog pathway.
Wei Huang   +7 more
wiley   +1 more source

A phase 4, open-label, multicenter study of the safety and efficacy of agalsidase beta in Chinese patients with Fabry disease. [PDF]

open access: yesOrphanet J Rare Dis
Ren H   +14 more
europepmc   +1 more source

Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium

open access: yesDevelopment, Growth &Differentiation, EarlyView.
ABSTRACT Odor information processing begins in the olfactory epithelium (OE), which in mice is spatially divided into two zones: the dorsomedial zone (D‐zone), responsible for innate aversive behaviors, and the ventrolateral zone (V‐zone), associated with learning‐dependent behaviors.
Anzu Kuriyama, Carina Hanashima
wiley   +1 more source

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