Results 151 to 160 of about 25,666 (269)

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Sodium glucose cotransporter‐2 (SGLT2) inhibitors are a class of antidiabetics with benefits including HbA1c‐lowering, weight loss, cardiovascular and renal protection in addition to adverse effects including genitourinary tract infections, ketoacidosis, and bone loss.
May E. Montasser, Salma A. Bargal, Elizabeth A. Streeten, Hilary B. Whitlatch, Zhinous Shahidzadeh Yazdi, Jordin Sirody, Rosanna Kiplagat, Merna Beshara, Jeffrey R. O’Connell, Simeon I. Taylor, Amber L. Beitelshees   +10 more
wiley   +1 more source

Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4671-4682, June 2026.
ABSTRACT Introduction Oxytocin is expressed throughout the small intestine, suggesting a role for oxytocin in postprandial metabolism. Accordingly, single‐dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on ad libitum food intake, appetite sensations ...
Ida M. Gether, Vivian Kliim‐Hansen, Petur T. Olafsson, Miriam G. Pedersen, Casper K. Nielsen, Anne‐Marie Ellegaard, Mikkel B. Christensen, Jens F. Rehfeld, Jørn W. Helge, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +13 more
wiley   +1 more source

Severe Hypertriglyceridemia Without Pancreatitis Causing Total Pseudohypocalcemia With True Ionized Symptomatic Hypocalcemia: A Diagnostic Pitfall

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Severe hypertriglyceridemia (HTG) can interfere with laboratory assays. HTG‐induced pancreatitis usually presents with hypocalcemia, but the effect of severe HTG, with no associated pancreatitis, on calcium levels is not well described. We present a 25‐year‐old male with severe HTG and diabetes who presented with generalized weakness, nausea ...
Mohamed Abuelazm, Marwah Algodi, Ahmed W. Hageen, Bassam Al Haly, Asawer Alsaeedi, Abdelrahman Awad, Hatem Eltaly, Omar Saab   +7 more
wiley   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du, Lingnian Zeng, Chan Liu, Huyao Zhou, Xia Wang, Qing Ai, Jinpiao Zhu, Nong Xiao   +7 more
wiley   +1 more source

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids. [PDF]

Cancers (Basel), 2023
Sever T, Ellidokuz EB, Basbinar Y, Ellidokuz H, Yilmaz ÖH, Calibasi-Kocal G.   +5 more
europepmc   +1 more source

The effects of maternal fasting during Ramadan on birth and adult outcomes [PDF]

We use the Islamic holy month of Ramadan as a natural experiment for evaluating the short and long-term effects of fasting during pregnancy. Using Michigan natality data we show that in utero exposure to Ramadan among Arab births results in lower ...
Bhashkar Mazumder, Douglas Almond
core  

Polyhydroxyalkanoates as Sustainable Agricultural Plastics: Processing Strategies, Performance, and Environmental Perspectives

Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
This review highlights polyhydroxyalkanoates (PHAs) as biodegradable materials for agricultural plastics. It outlines how composition, processing, and formulation strategies shape material properties and end‐of‐life behavior. Applications in films and foams are discussed alongside current limitations in cost and scalability, emphasizing emerging ...
Giulia de Simão de Sousa, Athanasios Latras, Carmen Fernández, Luis Francisco Mínguez Enkovaara, Amparo Jiménez‐Quero   +4 more
wiley   +1 more source

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2489-2499, May 2026.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech, Sarah L. Manske, Paul G. Mullins, Tiffany K. Bell, Ashley D. Harris   +4 more
wiley   +1 more source