Allergy, Asthma & Clinical Immunology, 2016 BackgroundResearch suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam allergy following allergy patient ...
E. Abrams +4 more
semanticscholar +1 more source
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +2 more sources
Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams [PDF]
, 2018 Glycosylation significantly alters the biological and physicochemical properties of small molecules. beta-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In
D'hooghe, Matthias +8 more
core +1 more source
Extended Infusions of Meropenem for Febrile Neutropenia [PDF]
, 2019 Background: Neutropenic fever is an oncologic emergency that requires quick intervention with anti-pseudomonal beta-lactam antibiotics, such as meropenem.
Przybylski, PharmD, Daniel J +1 more
core +1 more source
Risk factors and outcomes for ineffective empiric treatment of sepsis caused by gram-negative pathogens: Stratification by onset of infection [PDF]
, 2017 Sepsis and septic shock remain serious consequences of infections, with reported mortality rates in excess of 40 percent. Timely antibiotic therapy in cases of sepsis and septic shock is recognized as an important determinant of outcome.
Hampton, Nicholas +2 more
core +2 more sources
Critical Care, 2015 Beta-lactam antibiotics form the backbone of treatment for Gram-negative pneumonia in mechanically ventilated patients in the intensive care unit. However, this beta-lactam antibiotic backbone is increasingly under pressure from emerging resistance ...
M. Bassetti, T. Welte, R. Wunderink
semanticscholar +1 more source
Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population [PDF]
, 2020 Since antibiotic resistance is a major threat to global health, recent observations that the traditional test of minimum inhibitory concentration (MIC) is not informative enough to guide effective antibiotic treatment are alarming.
Debski, Pawel R. +9 more
core +1 more source
Endopeptidase-Mediated Beta Lactam Tolerance
PLoS Pathogens, 2015 In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g.
Tobias Dörr, B. M. Davis, M. Waldor
semanticscholar +1 more source
Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations [PDF]
, 1996 The most important pharmacodynamic parameter for beta-lactam antibiotics has been shown to be the time above the MIC, which is used as an argument to administer beta-lactam antibiotics by continuous infusion.
Mouton, J.W. (Johan), Vinks, A.A.
core
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]
, 2016 Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
A +173 more
core +4 more sources