Results 11 to 20 of about 637,109 (288)

Evolutionary ecology of beta-lactam gene clusters in animals [PDF]

, 2017
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida.
Faddeeva-Vakhrusheva, Anna, Roelofs, Dick, Nico M. van Straalen, Matty P. Berg, Brouwer, Abraham, Janine Mariën, Abraham Brouwer, Schol, Tim, Agamennone, Valeria, Alexander Blanke, Mariën, Janine; id_orcid, Anna Faddeeva-Vakhrusheva, Tim Schol, Berg, Matty P, Blanke, Alexander, van Straalen, Nico M, Suring, Wouter, Roelofs, Dick; id_orcid, Berg, Matty P; id_orcid, Mariën, Janine, Dick Roelofs, Valeria Agamennone, Karen Meusemann, null null, Meusemann, Karen, Wouter Suring   +25 more
core   +22 more sources

beta-Lactam Allergy in Children [PDF]

, 2021
Objective: beta-lactam antibiotic allergy is the most common drug allergy in children. Most of the patients with suspected reactions to beta-lactam antibiotics can actually tolerate these drugs.
YÜCEL, Esra, Guler, Nermin, TAMAY, Zeynep Ülker, SÜLEYMAN, Ayşe, Yararli, Ahmet Ilhan   +4 more
core   +1 more source

Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador [PDF]

, 2023
Multidrug-resistant bacteria present resistance mechanisms against β-lactam antibiotics, such as Extended-Spectrum Beta-lactamases (ESBL) and Metallo-β-lactamases enzymes (MBLs) which are operon encoded in Gram-negative species.
Gabriela N. Tenea, Castillejo, Pablo, Hernández Alomía, Fernanda, Jarrín-V., Pablo, Molina, Alfonso, Carlos Bastidas-Caldes, Pablo Jarrín-V., Tenea, Gabriela, Fernanda Hernández-Alomía, Pablo Castillejo, C. Alfonso Molina, Bastidas Caldes, Carlos, Ballesteros Redondo, María Isabel, Isabel Ballesteros   +13 more
core   +1 more source

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing [PDF]

, 2022
The increasing threat of drug resistance and a stagnated pipeline of novel therapeutics endanger the eradication of tuberculosis. Beta-lactams constitute promising additions to the current therapeutic arsenal and two carbapenems are included in group C ...
Olivença, Francisco, Silveiro, Cátia, Catalão, Maria João, Miragaia, Maria, Gomes, João Paulo, Nunes, Alexandra, Macedo, Rita, Pires, David, Anes, Elsa   +8 more
core   +1 more source

Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology

Allergy, Asthma & Clinical Immunology, 2020
The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public health. This article provides an overview of
Samira Jeimy, Moshe Ben-Shoshan, Elissa M. Abrams, Anne K. Ellis, Lori Connors, Tiffany Wong   +5 more
doaj   +1 more source

Comparative efficacy of azithromycin versus clarithromycin in combination with beta-lactams to treat community-acquired pneumonia in hospitalized patients: a systematic review

Journal of International Medical Research, 2021
Objective The objective was to compare the efficacy of azithromycin and clarithromycin in combination with beta-lactams to treat community-acquired pneumonia among hospitalized adults.
Jumana Al-Salloum, Syed Wasif Gillani, Rana Kamran Mahmood, Shabaz Mohiuddin Gulam   +3 more
doaj   +1 more source

Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus

Frontiers in Molecular Biosciences, 2021
Methicillin-resistant S. aureus (MRSA) are resistant to beta-lactams, but synergistic activity between beta-lactams and glycopeptides/lipopeptides is common.
Rutan Zhang, Ismael A. Barreras Beltran, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Kelly M. Hines, Stephen J. Salipante, Libin Xu, Brian J. Werth   +9 more
doaj   +1 more source

Documenting Penicillin Allergy: The Impact of Inconsistency. [PDF]

PLoS ONE, 2016
BACKGROUND:Allergy documentation is frequently inconsistent and incomplete. The impact of this variability on subsequent treatment is not well described. OBJECTIVE:To determine how allergy documentation affects subsequent antibiotic choice.
Nirav S Shah, Jessica P Ridgway, Natasha Pettit, John Fahrenbach, Ari Robicsek   +4 more
doaj   +1 more source

Analysis of a beta-lactam allergy assessment protocol challenging diverse reported allergies managed by an antimicrobial stewardship program

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Objective: To assess the safety and efficacy of a novel beta-lactam allergy assessment algorithm managed by an antimicrobial stewardship program (ASP) team. Design: Retrospective analysis.
Max W. Jacobs, Derek N. Bremmer, Nathan R. Shively, Matthew A. Moffa, Tamara L. Trienski, Dustin R. Carr, Carley A. Buchanan, Thomas L. Walsh   +7 more
doaj   +1 more source

Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models

Antibiotics, 2023
In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood ...
André Wieringa, Tim M. J. Ewoldt, Ravish N. Gangapersad, Matthias Gijsen, Nestor Parolya, Chantal J. A. R. Kats, Isabel Spriet, Henrik Endeman, Jasper J. Haringman, Reinier M. van Hest, Birgit C. P. Koch, Alan Abdulla   +11 more
doaj   +1 more source