Results 11 to 20 of about 824,973 (281)

Beta-lactam resistance in Campylobacter [PDF]

, 2011
Resistance to β-lactam antibiotics in Campylobacter is often associated with the production of a β-lactamase; to date the genomically encoded bla\(_{OXA-61}\) and the closely related cj0299 are the only described β-lactamase genes of Campylobacter ...
Stones, Leanne
core   +7 more sources

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Hadfield, Peter S., Page, Michael I., Casey, Lorraine A., Vilanova, Bartholomew, Galt, Ronald H. B.   +4 more
core   +5 more sources

Studies of beta-lactam degradation [PDF]

, 1984
The work discussed in this thesis falls into six parts. The first part (Chapter 1) is an introduction which deals with the history, structure, nomenclature and chemistry of beta-lactam antibiotics.
Alan McGlynn (7166168)
core   +7 more sources

Evolutionary ecology of beta-lactam gene clusters in animals [PDF]

, 2017
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida.

core   +13 more sources

Documenting Penicillin Allergy: The Impact of Inconsistency. [PDF]

PLoS ONE, 2016
BACKGROUND:Allergy documentation is frequently inconsistent and incomplete. The impact of this variability on subsequent treatment is not well described. OBJECTIVE:To determine how allergy documentation affects subsequent antibiotic choice.
Nirav S Shah, Jessica P Ridgway, Natasha Pettit, John Fahrenbach, Ari Robicsek   +4 more
doaj   +1 more source

Analysis of a beta-lactam allergy assessment protocol challenging diverse reported allergies managed by an antimicrobial stewardship program

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Objective: To assess the safety and efficacy of a novel beta-lactam allergy assessment algorithm managed by an antimicrobial stewardship program (ASP) team. Design: Retrospective analysis.
Max W. Jacobs, Derek N. Bremmer, Nathan R. Shively, Matthew A. Moffa, Tamara L. Trienski, Dustin R. Carr, Carley A. Buchanan, Thomas L. Walsh   +7 more
doaj   +1 more source

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing [PDF]

, 2022
The increasing threat of drug resistance and a stagnated pipeline of novel therapeutics endanger the eradication of tuberculosis. Beta-lactams constitute promising additions to the current therapeutic arsenal and two carbapenems are included in group C ...
Olivença, Francisco, Silveiro, Cátia, Catalão, Maria João, Miragaia, Maria, Gomes, João Paulo, Nunes, Alexandra, Macedo, Rita, Pires, David, Anes, Elsa   +8 more
core   +1 more source

Clinical impact of using fluoroquinolone with low antimycobacterial activity on treatment delay in tuberculosis: Hospital-based and population-based cohort study

Journal of the Formosan Medical Association, 2020
Background/Purpose: Little remains known regarding whether newer FQ with less anti-mycobacterial activity (gemifloxacin) would reduce treatment delay. Methods: We identified one hospital-based cohort (HBC) and one population-based cohort (PBC) including ...
Meng-Rui Lee, Chih-Hsin Lee, Jann-Yuan Wang, Shih-Wei Lee, Jen-Chung Ko, Li-Na Lee   +5 more
doaj   +1 more source

Beta-lactam dosing during continuous renal replacement therapy: a survey of practices in french intensive care units

BMC Nephrology, 2022
Background Little information is available on current practice in beta-lactam dosing during continuous renal replacement therapy (CRRT). Optimized dosing is essential for improving outcomes, and there is no consensus on the appropriate dose regimens. The
Elodie Matusik, Justine Lemtiri, Guillaume Wabont, Fabien Lambiotte   +3 more
doaj   +1 more source

Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models

Antibiotics, 2023
In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood ...
André Wieringa, Tim M. J. Ewoldt, Ravish N. Gangapersad, Matthias Gijsen, Nestor Parolya, Chantal J. A. R. Kats, Isabel Spriet, Henrik Endeman, Jasper J. Haringman, Reinier M. van Hest, Birgit C. P. Koch, Alan Abdulla   +11 more
doaj   +1 more source