Results 31 to 40 of about 824,973 (281)

Molecular characterization of ESBL-producing Shigella sonnei isolates from patients with bacilliary dysentery in Lebanon

Journal of Infection in Developing Countries, 2009
Background: Emergence of extended-spectrum -lactamases (ESBLs) in Shigella species imparting resistance to third-generation cephalosporins is a growing concern worldwide. The aim of this study is to molecularly characterize the newly emerging beta-lactam
Ahmad H. Sabra, George F. Araj, Mireille M. Kattar, Roland Y. Abi-Rached, Marie-Therese Khairallah, John D. Glena, Ghassan M. Matar   +6 more
doaj   +1 more source

Beta-lactam levels by age (beef carcass counts are at the bottom of bars).

, 2019
Beta-lactam levels by age (beef carcass counts are at the bottom of bars).
Susan A. Olet (6194915), Paul Erasmus Alele (6194918), Yake Basulira (6194912)   +2 more
core   +1 more source

Role of a Real-Time TDM-Based Expert Clinical Pharmacological Advice Program in Optimizing the Early Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Beta-Lactams among Orthotopic Liver Transplant Recipients with Documented or Suspected Gram-Negative Infections

Antibiotics, 2023
(1) Objectives: To describe the attainment of optimal pharmacokinetic/pharmacodynamic (PK/PD) targets in orthotopic liver transplant (OLT) recipients treated with continuous infusion (CI) beta-lactams optimized using a real-time therapeutic drug ...
Milo Gatti, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +5 more
doaj   +1 more source

Ceftriaxone-resistant salmonella enterica serotype Newport, France. [PDF]

, 2008
The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 beta-lactamase (Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during 2000-2005.
Delauné, Aurélia, François-Xavier Weill, Sophie A. Granier, Whichard, Jean M., Mark Achtman, Sangal, Vartul, Millemann, Yves, Emmanuelle Espié, Patrick A.D. Grimont, Egorova, Svetlana, Mohammed Timinouni, Weill, François-Xavier, Marie Demartin, Vartul Sangal, Svetlana Egorova, Granier, Sophie, Demartin, Marie, Grimont, Patrick A. D., Granier, Sophie A., Yves Millemann, Achtman, Mark, Whichard, Jean, Fabre, Laëtitia, Pardos, Maria, Jean M. Whichard, Maria Pardos, Timinouni, Mohammed, Laëtitia Fabre, Aurélia Delauné, Espié, Emmanuelle, Grimont, Patrick   +30 more
core   +1 more source

Smart Antibacterial Coatings: Harnessing Bacterial Redox Activity for Infection Control

Advanced Materials Interfaces, EarlyView.
In this study, we have shown that ceftazidime‐loaded poly(3,4‐ethylenedioxythiophene) (PEDOT@CAZ) functions as a smart, redox‐responsive antibacterial coating that couples bacterial electrical activity with localized antibiotic delivery. Shewanella oneidensis and Pseudomonas aeruginosa induced distinct redox responses in PEDOT, reflecting their ...
Abdullah, Szymon Smołka, Kamran Ayaz, Sara Shakibania, Sajida Maryam, Taral Patel, Roman Turczyn, Ewa Zabłocka‐Godlewska, Katarzyna Krukiewicz   +8 more
wiley   +1 more source

Comparison of combination therapy with beta-lactam and aminoglycoside antibiotics versus monotherapy with beta-lactam antibiotics on clinical outcomes in adult sepsis patients at RSUP Dr. Kariadi in Semarang [PDF]

BIO Web of Conferences
Sepsis is a complex clinical syndrome resulting from the body’s systemic response to an infection that causes organ dysfunction and requires treatment with broad-spectrum antibiotics. Beta-lactams are broad-spectrum antibiotics used either as monotherapy
Dilaga Arroyani Asa, Fawwaz Naufal Erlang, Savitri Annisa Aulia, Faturrachman Gavriel Fauzan   +3 more
doaj   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Why We May Need Higher Doses of Beta-Lactam Antibiotics: Introducing the ‘Maximum Tolerable Dose’

Antibiotics, 2022
The surge in antimicrobial resistance and the limited availability of new antimicrobial drugs has fueled the interest in optimizing antibiotic dosing. An ideal dosing regimen leads to maximal bacterial cell kill, whilst minimizing the risk of toxicity or
Sofie A. M. Dhaese, Eric A. Hoste, Jan J. De Waele   +2 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source