Results 31 to 40 of about 637,109 (288)

Mutations in beta-lactam resistance determining regions and beta lactam resistance profiles. [PDF]

, 2018
Mutations in beta-lactam resistance determining regions and beta lactam resistance profiles.
Ajay Kumar Vijay (5802035), Gurjeet Singh Kohli (5802038), Scott A. Rice (143316), Dinesh Subedi (5802032), Mark Willcox (749527)   +4 more
core   +1 more source

Setting the Beta-Lactam Therapeutic Range for Critically Ill Patients: Is There a Floor or Even a Ceiling?

Critical Care Explorations, 2021
OBJECTIVES:. Beta-lactam antibiotics exhibit high interindividual variability in drug concentrations in patients with critical illness which led to an interest in the use of therapeutic drug monitoring to improve effectiveness and safety.
Erin F. Barreto, PharmD, MSc, Andrew J. Webb, PharmD, Gwendolyn M. Pais, PhD, Andrew D. Rule, MD, Paul J. Jannetto, PhD, Marc H. Scheetz, PharmD, MSc   +5 more
doaj   +1 more source

Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study

Implementation Science Communications, 2021
Background Beta-lactams (i.e., penicillins, cephalosporins, carbapenems, monobactams) are the most widely used class of antibiotics in critically ill patients.
Erin F. Barreto, Andrew D. Rule, Mohammad H. Alshaer, Jason A. Roberts, Mohd Hafiz Abdul Aziz, Marc H. Scheetz, Kristin C. Mara, Paul J. Jannetto, Ognjen Gajic, John C. O’Horo, Kasey R. Boehmer   +10 more
doaj   +1 more source

Functionalization of N-[(Silyl)methyl]-beta-lactam Carbanions with Carbon Electrophiles [PDF]

, 2006
Latent acidity of alpha-alkyl-alpha-amino-N-[(silyl)methyl]-beta-lactams enabled a concise entry to lithium nonenolate N-methyl-azetidinone carbanions lithiated alpha' to the beta-lactam nitrogen, owing to the stabilizing "alpha-effect" of one or two ...
Palomo, Claudio, Fratila, Raluca M., Cuerdo, Lourdes, Linden, Anthony, Benito, Ana M., Aizpurua, Jesús M., Miranda, José Ignacio   +6 more
core   +1 more source

Therapeutic drug monitoring of beta-lactam antibiotics in the ICU [PDF]

, 2020
Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes while minimizing the risk of toxicity and antimicrobial therapy.
Boelens, Jerina, De Waele, Jan, Van Vooren, Sarah, Dhaese, Sofie   +3 more
core   +1 more source

Ceftriaxone-resistant salmonella enterica serotype Newport, France. [PDF]

, 2008
The multidrug-resistant (MDR) Salmonella enterica serotype Newport strain that produces CMY-2 beta-lactamase (Newport MDR-AmpC) was the source of sporadic cases and outbreaks in humans in France during 2000-2005.
Delauné, Aurélia, François-Xavier Weill, Sophie A. Granier, Whichard, Jean M., Mark Achtman, Sangal, Vartul, Millemann, Yves, Emmanuelle Espié, Patrick A.D. Grimont, Egorova, Svetlana, Mohammed Timinouni, Weill, François-Xavier, Marie Demartin, Vartul Sangal, Svetlana Egorova, Granier, Sophie, Demartin, Marie, Grimont, Patrick A. D., Granier, Sophie A., Yves Millemann, Achtman, Mark, Whichard, Jean, Fabre, Laëtitia, Pardos, Maria, Jean M. Whichard, Maria Pardos, Timinouni, Mohammed, Laëtitia Fabre, Aurélia Delauné, Espié, Emmanuelle, Grimont, Patrick   +30 more
core   +1 more source

Molecular characterization of ESBL-producing Shigella sonnei isolates from patients with bacilliary dysentery in Lebanon

Journal of Infection in Developing Countries, 2009
Background: Emergence of extended-spectrum -lactamases (ESBLs) in Shigella species imparting resistance to third-generation cephalosporins is a growing concern worldwide. The aim of this study is to molecularly characterize the newly emerging beta-lactam
Ahmad H. Sabra, George F. Araj, Mireille M. Kattar, Roland Y. Abi-Rached, Marie-Therese Khairallah, John D. Glena, Ghassan M. Matar   +6 more
doaj   +1 more source

Role of a Real-Time TDM-Based Expert Clinical Pharmacological Advice Program in Optimizing the Early Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Beta-Lactams among Orthotopic Liver Transplant Recipients with Documented or Suspected Gram-Negative Infections

Antibiotics, 2023
(1) Objectives: To describe the attainment of optimal pharmacokinetic/pharmacodynamic (PK/PD) targets in orthotopic liver transplant (OLT) recipients treated with continuous infusion (CI) beta-lactams optimized using a real-time therapeutic drug ...
Milo Gatti, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +5 more
doaj   +1 more source

Degradation of beta-lactams in bacterial growth media [PDF]

, 2020
The dataset contains growth curves of E. coli RJA002 in various growth media in the presence of beta-lactam antibiotics. These growth curves were used to determine the degradation rate of these antibiotics in a range of experimental conditions.
Allen, Rosalind J, Vass, Hugh, Brouwers, Rebecca   +2 more
core   +1 more source

Antibacterial activity of beta-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae [PDF]

, 1984
In order to define the characteristics of the antibacterial activity of beta-lactam antibiotics in the treatment of bacterial meningitis, the relationship between cerebrospinal fluid (CSF) drug concentrations and the rate of bacterial killing was ...
M. G. Tauber, M. A. Sande, Doroshow, CA, M. G. Rusnak, Täuber, MG, Drake, TA, C. J. Hackbarth, T. A. Drake, Hackbarth, CJ, C. A. Doroshow, Rusnak, MG, Sande, MA   +11 more
core   +1 more source