Results 261 to 270 of about 153,260 (300)

Sulbactam: a beta-lactamase inhibitor.

Clinical pharmacy, 1988
The chemistry, pharmacology, microbiology, pharmacokinetics, clinical efficacy, and adverse effects of sulbactam are reviewed. Sulbactam is a competitive, irreversible beta-lactamase inhibitor. Its binding to penicillin-binding proteins imparts weak intrinsic antibacterial activity.
J K, Noguchi, M A, Gill
openaire   +1 more source

Nanomolar beta-lactamase inhibitors

2003
New .alpha.-boronated N-alkylamides, R1C(O)NHCHR2B(OH)2 (R1 = H, organyl, excluding R1 = Me, Ph; R2 = heterocyclyl, cycloalkenyl, alkenyl, alkyl), preferably N-acyl-3-aminomethylbenzoates (.alpha.R)-RC(O)NHCH[B(OH)2]-1,3-C6H4X [15-17; X = CO2H, R = Me, 2-thienylmethyl, 3-(2-chlorophenyl)-5-methylisoxazol-4-yl; 21, X = H, R = 2-thienylmethyl], designed ...
SHOICHET B. K, PRATI, Fabio
openaire   +1 more source

[Development of beta-lactamase inhibitors].

Nihon rinsho. Japanese journal of clinical medicine, 1997
The proportion of beta-lactamase producing bacteria in each species of clinical isolates is high (over 90%) in these years. According to the survey of bacterial resistance in 1995, higher proportion of resistant bacterial species against ampicillin, piperacillin (PIPC), cefazolin, cefotiam was observed.
A, Hyodo, F, Higashitani, K, Nishida, C, Kunugita, N, Unemi   +4 more
openaire   +1 more source

Beta-Lactamase Inhibitors

2015
P A, Lambert, C E, Sansom
openaire   +2 more sources

Beta-lactam/beta-lactamase inhibitors versus carbapenem for bloodstream infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae: systematic review and meta-analysis.

International Journal of Antimicrobial Agents, 2018
M. Sfeir, G. Askin, P. Christos
semanticscholar   +1 more source

Covalent docking of selected boron-based serine beta-lactamase inhibitors

Journal of Computer-Aided Molecular Design, 2015
Jacopo Sgrignani, Beatrice Novati, G. Colombo, G. Grazioso   +3 more
semanticscholar   +1 more source

Pharmacokinetic properties of beta-lactamase inhibitors.

International journal of clinical pharmacology and therapeutics, 1999
In recent years, the use of combinations of beta-lactam-antibiotics with beta-lactamase inhibitors has been proven to be a useful and effective strategy to improve upon the therapeutic value of beta-lactam antibiotics. The objective of this article is to evaluate the pharmacokinetic properties of three commercially available beta-lactamase inhibitors ...
A, de la Pena, H, Derendorf
openaire   +1 more source

Beta-lactams and Beta-lactamase-inhibitors in current- or potential-clinical practice: A comprehensive update

Critical reviews in microbiology, 2009
M. Shahid, F. Sobia, Anuradha Singh, Ashraf Malik, Haris M. Khan, D. Jonas, P. Hawkey   +6 more
semanticscholar   +1 more source

Development of beta-lactamase inhibitors.

The Journal of reproductive medicine, 1990
The resistance of bacteria to beta-lactam antibiotics was first associated with the production of the enzyme beta-lactamase as long ago as 1940. Since then, increasing numbers of beta-lactamase-producing bacteria capable of inactivating penicillins and cephalosporins have been isolated clinically.
openaire   +1 more source

Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate and sulbactam combined with extended-spectrum penicillins against ticarcillin-resistant Enterobacteriaceae and pseudomonads.

Journal of Antimicrobial Chemotherapy, 1986
M. Jacobs, S. Aronoff, S. Johenning, S. Yamabe   +3 more
semanticscholar   +1 more source