Results 211 to 220 of about 612,998 (297)

Artificial Intelligence to Close the Gap between Pharmacokinetic/Pharmacodynamic Targets and Clinical Outcomes in Critically Ill Patients: A Narrative Review on Beta Lactams. [PDF]

Antibiotics (Basel)
Gonçalves Pereira J, Fernandes J, Mendes T, Gonzalez FA, Fernandes SM.   +4 more
europepmc   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 394-398, August 2026.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Two Novel 1,4‐Naphthoquinone Derivatives as Potent Agents Against Multidrug‐Resistant Staphylococcus aureus and Pathogenic Gram‐Positive Bacteria

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Drug‐resistant bacteria such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Quinolone‐resistant S. aureus (QRSA), are a growing problem, creating a need for the development of novel antimicrobial agents. In this study, we designed and synthesized two novel 1,4‐naphthoquinone derivatives, LHN‐1034 and LHN‐1035, and evaluated their ...
HyunChan Song, Haena Lee, Ji‐Hyun Yoon, Hyunkyung Choi, Hakwon Kim, Ki‐Young Kim   +5 more
wiley   +1 more source

A whole-cell hypersensitive biosensor for beta-lactams based on the AmpR-AmpC regulatory circuit from the Antarctic Pseudomonas sp. IB20. [PDF]

Microb Biotechnol
Higuera-Llantén S, Alcalde-Rico M, Vasquez-Ponce F, Ibacache-Quiroga C, Blazquez J, Olivares-Pacheco J.   +5 more
europepmc   +1 more source

Inhibition of Staphylococcus aureus Biofilm Formation by Plumbagin Combined With Ceftazidime and Cefazolin

eFood, Volume 7, Issue 4, August 2026.
Plumbagin can be potentially used in combination with antibiotics, as a safer, and effective agent solution against biofilms formed by Staphylococcus aureus in the healthcare, and food industry. ABSTRACT Biofilm‐forming Staphylococcus aureus is the major cause several foodborne diseases, and pose a serious challenge in the healthcare, and food industry.
Borel Ndezo Bisso, Humera Jahan, Akim Socohou, Mamadou Sawadogo, Jean Paul Dzoyem, M. Iqbal Choudhary   +5 more
wiley   +1 more source

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales. [PDF]

BMC Infect Dis
Sader HS, Kimbrough JH, Mendes RE, Castanheira M.   +3 more
europepmc   +1 more source