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, 2017 This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis ...
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Tuberculosis and Beta-Lactam Antibiotics
Future Microbiology, 2020Tuberculosis (TB) is one of the oldest health problems in the world and it remains unresolved. Multidrug-resistant-TB and extensively resistant-TB are a serious problem for control programs. The evaluation of available antibiotics has gained importance in recent years for the treatment of resistant TB.
Mehmet Akif Gun +2 more
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Beta lactam allergy and resensitization in children with suspected beta lactam allergy
Clinical & Experimental Allergy, 2009SummaryBackground In patients who were clinically diagnosed as having beta lactam allergy and had negative skin tests, the rates of reported resensitization to beta lactams after subsequent exposures, vary significantly. Some allergists advocate skin testing before every exposure to beta lactams.Objective We sought to determine the true ...
J, Hershkovich +4 more
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Penicillin and Beta-Lactam Hypersensitivity
Immunology and Allergy Clinics of North America, 2017Ten percent of patients report penicillin allergy, but more than 90% of these individuals can tolerate penicillins. Skin testing remains the optimal method for evaluation of possible IgE-mediated penicillin allergy and is recommended by professional societies, as the harms for alternative antibiotics include antimicrobial resistance, prolonged ...
Daniel, Har, Roland, Solensky
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Beta‐lactam biosynthetic genes
Medicinal Research Reviews, 1989Article de synthese sur les genes impliques dans la biosynthese des beta-lactam; clonage moleculaire et expression chez E.
T D, Ingolia, S W, Queener
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Monocyclic antibiotic .beta.-lactams
Journal of Medicinal Chemistry, 1975The preparation and antimicrobial activity of a series of beta-lactams (3a-f) are described. These compounds were prepared from the 2+2 cycloaddition of beta,beta-disubstituted enamines with aryl isocyanates; compounds 3a-f underwent facile beta-lactam ring fission between aminal carbon atom C4 and the lactam nitrogen N1.
R F, Abdulla, K H, Fuhr
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A new synthesis of .beta.-lactams
Journal of the American Chemical Society, 1977The authors recently reported the regiospecific addition of heteroatomic nucleophiles to a number of Fp(olefin) cations (Fp = eta/sup 5/-C/sub 5/H/sub 5/Fe(CO)/sub 2/). Furthermore, it has been shown that oxidatively induced ligand transfer in FpR complexes (R-Fe-CO ..-->..
P K, Wong +3 more
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Hypersensitivity Reactions to Beta-lactams
2013Beta-lactam antibiotics (BLs) are the most frequent cause of hypersensitivity reactions mediated by specific immunological mechanisms, with two main types, IgE reactions or T-cell-dependent responses. From a practical point of view, these reactions can be classified into immediate, for those appearing within 1 h after drug intake, and non-immediate ...
Maria J, Torres +3 more
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Continuous infusion of beta-lactams
Current Opinion in Critical Care, 2007Continuous infusion of beta-lactam antibiotics is becoming increasingly popular. The background and current clinical evidence are discussed. Tools to apply continuous infusion are analyzed.One randomized controlled trial in an ICU setting and two nonrandomized controlled trials have shown continuous infusion to be more beneficial than intermittent ...
Johan W, Mouton, Alexander A, Vinks
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