Results 131 to 140 of about 939,341 (289)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway

open access: yesNeuropsychiatric Disease and Treatment, 2019
Hui He,1 Xiufang Li,2 Yuling He1 1Department of Emergency, Zhuji People’s Hospital of Zhejiang Province, Zhuji, Zhejiang, China; 2Department of Pathology, Zhuji People’s Hospital of Zhejiang Province, Zhuji, Zhejiang, China Background ...
He H, Li X, He Y
doaj  

A note on the generalized Gaussian Estrada index and Gaussian subgraph centrality of graphs

open access: yesAIMS Mathematics
Let $ H $ be a simple, undirected, connected graph represented by its adjacency matrix $ \mathit{\boldsymbol{A}} $. For a vertex $ u \in V(H) $, the generalized Gaussian subgraph centrality of $ u $ in $ H $ is $ GSC (u, \beta) = \exp \left(- \beta ...
Yang Yang   +3 more
doaj   +1 more source

Health Inequality, Education and Medical Innovation [PDF]

open access: yes
Recent studies suggest that health inequalities across socio-economic groups in the US are large and have been growing. We hypothesize that, as in other, non-health contexts, this pattern occurs because more educated people are better able than to take ...
Adriana Lleras-Muney, Sherry Glied
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Corporate Financial Policies and Performance Around Currency Crises [PDF]

open access: yes
Using data from 17 countries that have suffered a currency crisis, this paper studies firm-level leverage and performance measures before and after a crisis has occurred.
Bris, Arturo   +2 more
core  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

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