Results 111 to 120 of about 607,752 (259)
Risk Management and Insurance Review, EarlyView.Abstract This study examines whether underwriting methods—representation, medical examination, extra premiums, and coverage—effectively mitigate adverse selection using data from an insurance company. Regarding representation, we focus on statements disclosing pre‐existing medical conditions.
Chia‐Ling Ho +3 more
wiley +1 more source
Genotype-phenotype analysis in HbS-beta-thalassemia
, 1997 Genotypes and phenotypes were studied in 31 Turkish HbS-beta-thalassemia patients. In 19 patients the beta-thalassemia mutations were beta(+) and in 12 the beta(0) phenotype. The IVSI-110 mutation was found in 45% of the patients.
Altay, C +8 more
core +1 more source
Transfusion Medicine, EarlyView.Abstract Objective This study aimed to analyse the distribution and demand patterns of antigen‐negative red blood cells (RBCs) in Shandong Province, China (2022–2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a ...
Aiping Zhao +7 more
wiley +1 more source
Natural History of Chronic Kidney Disease in Sickle Cell Disease
American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley +1 more source
Genetic analysis of beta-thalassemia major and beta-thalassemia intermedia in Brazil
, 1998 The development of methodologies to identify the molecular lesions responsible for different types of beta-thalassemia has made it possible to correlate these data with clinical and hematological severity.
Costa, Fernando Ferreira [UNIFESP] +7 more
core +1 more source
A Novel Plasma Heme Assay Reveals Disease Severity in Beta‐Thalassemia and Sickle Cell Anemia
American Journal of Hematology, Volume 101, Issue 7, Page 1706-1716, July 2026.ABSTRACT Anemia results from imbalanced hemoglobin or red blood cell production and clearance. Hemolytic anemia, caused by premature red blood cell removal, can be intravascular (in blood) or extravascular (erythrophagocytosis). Hemolysis is common in Sickle Cell Disease (SCD) and Beta‐Thalassemia anemia (β‐thalassemia), the most prevalent inherited ...
Laurent Kiger +14 more
wiley +1 more source
Acta Paediatrica, Volume 115, Issue 7, Page 1322-1372, July 2026.Importance of psychosocial support. ABSTRACT Aim The aim of this scoping review was to identify, examine, and summarize available evidence regarding psychosocial supports provided to children with a chronic disease when admitted to hospital and their parents. Method The JBI methodology for conducting and reporting scoping reviews was followed.
Lyndsay Jerusha MacKay +6 more
wiley +1 more source
Clinical Otolaryngology, Volume 51, Issue 4, Page 520-528, July 2026.ABSTRACT Objectives Sleep‐disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.
Shifa Hamdule +5 more
wiley +1 more source
European Journal of Haematology, Volume 117, Issue 1, Page 161-173, July 2026.ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam +12 more
wiley +1 more source