Lived experiences of Iranian parents of beta-thalassemia children
Introduction Thalassemia is a chronic blood disease, which imposes adverse effects on patients and their families. Parents of such patients, given that they had the thalassemia trait, hold themselves responsible for their children’s disease in addition ...
Aziz Shahraki-Vahed+3 more
semanticscholar +1 more source
The compound state: Hb S/beta-thalassemia
The polymerization of deoxygenated Hb S (sickling) is theprimary event in the molecular pathogenesis of SCD. How-ever, this event is highly dependent on the intracellular Hbcomposition; in other words, it is dependent on the concen-tration of Hb S, and type and concentration of the other typesof Hb.
openaire +4 more sources
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura+8 more
wiley +1 more source
بررسی حاملگی در بيماران تالاسمی درمان شده در دو مرکز حضرت علیاصغر و درمانگاه تالاسمی: نتايج حاصل برای مادران و نوزادان آنهاPregnancy in Patients with Treated Beta Thalassemia Major in 2 Centers(Ali Asghar Children Hospital & Thalasemia Clinic): Outcome for Mothers and Newborn Infants [PDF]
زمينه و هدف: بتاتالاسمی ماژور، آنمی شديد وابسته به تزريق خون است که به علت رسوب آهن حاصل از تزريق خون مکرر در غدد آندوکرين باعث نازايی میشود. در گذشته، حاملگی در تعداد کمی از بيماران تالاسمی گزارش میشد.
آذرکيوان, آزیتا+2 more
core
Hemoglobinopatias no Distrito Federal, Brasil [PDF]
Em uma amostra de 3137 pessoas, residentes no Distrito Federal, foram detectadas as seguintes hemoglobinas: em 3009(95,92%) HbAA; em 91 (2,90%) HbAS; em 20(0,64%) HbAC; em 8 (0,26%) talassemia beta minor; em 5(0,16%) HbAJ alfa; em 3 (0,09%) HbAM e em 1 ...
Adorno, José+15 more
core +5 more sources
Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley +1 more source
Effect of booklet and combined method on parents' awareness of children with β-thalassemia major disorder [PDF]
OBJECTIVE: To assess the effects of booklet and combining methods (lecture, video, etc.) on parents' awareness of children with beta-thalassemia major disorder.
Hasanpour-Dehkordi, A.+1 more
core
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R.+11 more
core +4 more sources
The Food and Agricultural Approaches to Reducing Malnutrition (FAARM) trial found no evidence that a 3‐year Homestead Food Production intervention reduced anaemia or micronutrient deficiencies among women and young children in rural Bangladesh. The intervention had improved diets and hygiene practices, but bigger changes may be needed.
Amanda S. Wendt+6 more
wiley +1 more source
Validity of naked eye single tube red cell osmotic fragility test (NESTROFT) in screening of beta-thalassemia trait [PDF]
زمینه و هدف: تالاسمی متداولترین اختلال تک ژنی است که رهایی از آن از طریق درمان قطعی ممکن نبوده و مستلزم پیشگیری از طریق به کارگیری یک روش قابل اعتماد و کم هزینه برای غربالگری ناقلین و در مرحله بعد ارایه آموزش، مشاوره ژنتیک، تشخیص قبل از تولد و خاتمه ...
Amini, S.A.+3 more
core