Results 61 to 70 of about 30,419 (262)

Perfil de beta talassemia heterozigota obtido a partir de análise data mining em banco de dados The profile of beta thalassemia obtained by data mining analysis in a database

Revista Brasileira de Hematologia e Hemoterapia, 2010
Variations in the phenotypic expression of heterozygous beta thalassemia reflect the formation of different populations. To better understand the profile of heterozygous beta-thalassemia of the Brazilian population, we aimed at establishing parameters to
Ana L. B. Domingos, Lucas A. Granzotto, Edis Belini Junior, Thiago Y. K. Oliveira, Ana C. B. Domingos, Claudia R. Bonini-Domingos   +5 more
doaj   +1 more source

Association Between Thalassemia and Leucocytic DNA Damage: A Pilot Study [PDF]

, 2022
Objectives: Thalassemia with frequent blood transfusion was considered under oxidative stress because of the chance of iron overload. Patients with thalassemia trait with no blood transfusion might also suffered from oxidative stress because of increased
CHAN, Charlton, Szeto, Yim
core   +1 more source

Understanding erythroid physiology and pathology in humanized mice: A closer look

British Journal of Haematology, Volume 206, Issue 5, Page 1272-1284, May 2025.
Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu, Chenfei Liu, Lezong Chen, Xumiao Zhang, Yinglin Su, Zhenzhen Chou, Yang Liang, Yuanbin Song   +7 more
wiley   +1 more source

Lack of awareness about thalassemia; a social factor in the propagation of beta thalassemia gene in Pakistan: A population study

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Background: Beta thalassemia is the most common genetic disorder in Pakistan. Thalassemia is a preventive disease a fact well demonstrated by countries such as Italy, Greece and Cyprus.
Muhammad Usman
doaj  

Premarital screening test results for beta thalassemia in Malatya Province

Medicine Science, 2021
Hemoglobinopathies are the most common monogenic hereditary diseases worldwide. After sickle-cell disease, beta thalassemia has the highest incidence. Premarital screening is performed to detect beta thalassemia carriers and prevent pathological births ...
Mehmet Erten
doaj   +1 more source

Restless legs syndrome/Willis–Ekbom disease prevalence in beta thalassemia patients [PDF]

, 2017
Purpose Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling.
Dimitriadou, Euthimia, Giannaki, Christoforos D., Hadjigeorgiou, Georgios M., Karatzaferi, Christina, Lavdas, Eleftherios, Sakkas, Giorgos K., Stefanidis, Ioannis, Tsekoura, Maria   +7 more
core   +1 more source

Long‐term efficacy and safety of mitapivat in non‐transfusion‐dependent α‐ or β‐thalassaemia: An open‐label phase 2 study

British Journal of Haematology, EarlyView.
Mitapivat is an oral activator of pyruvate kinase (PK), the enzyme responsible for the final step in glycolysis, and increases production of adenosine triphosphate (ATP), which may lead to improvements in red blood cell health, ineffective erythropoiesis and haemolysis.
Kevin H. M. Kuo, D. Mark Layton, Ashutosh Lal, Elliott P. Vichinsky, Jayme L. Dahlin, Shihao Shen, Gavrielle M. Price, Keely S. Gilroy, Jeremie H. Estepp, Hanny Al‐Samkari   +9 more
wiley   +1 more source

Dukungan Keluarga Dalam Merawat Anak Dengan Thalassemia Beta Mayor

Citra Delima, 2019
ABSTRAK Pendahuluan: Thalassemia merupakan penyakit anemia hemolitik yang diturunkan secara genetik. Indonesia termasuk salah satu Negara yang memiliki penduduk pembawa gena thalassemia dengan prevalensi sebesar 3-8%. Anak thalassemia beta mayor harus
Rezka Nurvinanda, Sri Mulatsih, Sri Hartini, Intansari Nurjannah   +3 more
doaj   +1 more source

Current status of beta‐thalassemia and its treatment strategies

Molecular Genetics & Genomic Medicine, 2021
Background Thalassemia is an inherited hematological disorder categorized by a decrease or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by one or more mutations in the beta‐globin gene.
Shaukat Ali, Shumaila Mumtaz, Hafiz Abdullah Shakir, Muhammad Khan, Hafiz Muhammad Tahir, Samaira Mumtaz, Tafail Akbar Mughal, Ali Hassan, Syed Akif Raza Kazmi, Sadia, Muhammad Irfan, Muhammad Adeeb Khan   +11 more
doaj   +1 more source

The role of red blood cell characteristics and viscosity in sickle cell retinopathy and maculopathy

British Journal of Haematology, EarlyView.
Sickle cell retinopathy and maculopathy are common ocular complications of sickle cell disease. This study assessed the contribution of red blood cell characteristics and blood viscosity to their development. HbSC patients with proliferative retinopathy showed a lower delta elongation index and point of sickling, while no link was found between whole ...
Rajani P. Brandsen, Roselie M. H. Diederen, Ingeborg Klaassen, Martijn Veldthuis, Herbert Korsten, Rob van Zwieten, Reinier O. Schlingemann, Erfan Nur, Bart J. Biemond   +8 more
wiley   +1 more source