Results 81 to 90 of about 48,747 (238)

Molecular analysis of beta-globin gene mutations among Thai beta-thalassemia children: results from a single center study

The Application of Clinical Genetics, 2014
Boonchai Boonyawat,1 Chalinee Monsereenusorn,2 Chanchai Traivaree2 1Division of Genetics, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; 2Division of Hematology/Oncology, Department of Pediatrics ...
Boonyawat B, Monsereenusorn C, Traivaree C   +2 more
doaj  

Fuzzy-Based Fusion Model for β-Thalassemia Carriers Prediction Using Machine Learning Technique

Advances in Fuzzy Systems
The abnormality of haemoglobin in the human body is the fundamental cause of thalassemia disease. Thalassemia is considered a common genetic blood condition that has received extensive investigation in medical research globally.
Muhammad Ibrahim, Sagheer Abbas, Areej Fatima, Taher M. Ghazal, Muhammad Saleem, Meshal Alharbi, Fahad Mazaed Alotaibi, Muhammad Adnan Khan, Muhammad Waqas, Nouh Elmitwally   +9 more
doaj   +1 more source

Patient‐Reported Outcomes With Luspatercept Through 5 Years of Treatment in Patients With Non‐Transfusion‐Dependent β‐Thalassemia Treated in the BEYOND Trial

European Journal of Haematology, EarlyView.
ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam, Maria Domenica Cappellini, Antonis Kattamis, Matthew Dyer, Ahmed Hnoosh, Laurie Eliason, Christopher G. Pelligra, Shien Guo, Yutian Mu, Loyse Felber Medlin, Marta Reverte, Kevin H. M. Kuo, Ali T. Taher   +12 more
wiley   +1 more source

Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)

Research in Molecular Medicine, 2017
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin ...
Hossein Karami, Hossein Jalali, Mehrad Mahdavi, Mohammad Reza Mahdavi   +3 more
doaj  

Intervention and Prevention of Hereditary Hemolytic Disorders in Two Ethnic Communities of Sundargarh District of Orissa, India: An Experience from KAP Studies [PDF]

, 2010
Hereditary hemolytic disorders are important public health challenges in India. They cause a high degree of morbidity, mortality and fetal wastage in vulnerable communities.
Balgir, RS
core   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Factors Influencing Beta-Thalassemia Awareness in Western India

National Journal of Community Medicine, 2016
Context: Beta-thalassemia is highly prevalent in western India. Our organization runs a screening and prevention program to create awareness and reduce the incidence of homozygous beta-thalassemia cases.
Ashwin P Patel, Prakash H Parmar2, Rupesh B Patel, Nikhil M Trivedi, Nileshkumar A Bhartiya   +4 more
doaj  

Quality of life among patients with beta-thalassemia major in Shahrekord city, Iran [PDF]

, 2016
Background and aims: Nowadays introduction of regular blood transfusion therapy has obviously improved the life expectancy of patients with thalassemia. However, these patients face with newer challenges which influence their quality of life (QoL).
Emadi Dehaghi, B., Mohammadi Farsani, S., Rasooli, L.   +2 more
core  

Beeta-talasseemia [PDF]

, 2006
Talasseemiad on pärilikud hemoglobinopaatiad, mis on põhjustatud sellest, et sünteesitakse ehituslikult anomaalset hemoglobiini (Hb) molekuli või toimub normaalse hemoglobiini mittepiisav süntees.
Grünberg, Heli, Mikkel, Sirje
core   +2 more sources

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source