Results 131 to 140 of about 267,362 (329)

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses

Neurobiology of Disease, 2005
There is accumulating evidence that CD8-positive (CD8+) T-cells and MHC-I expression may also play a role in neurodegeneration associated with multiple sclerosis (MS). We investigated the role of MHC-I and CD8+ T-cells by studying experimental autoimmune
Ralf A. Linker, Evelyn Rott, H.H. Hofstetter, T. Hanke, Klaus V. Toyka, Ralf Gold   +5 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.

PLoS Pathogens, 2008
The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F Zipfel   +7 more
doaj   +1 more source

beta(2)-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

, 2010
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in blood of patients with thrombosis or fetal loss. There is ample evidence that beta(2)-glycoprotein I (beta(2)GPI) is the major antigen for antiphospholipid ...
Agar, Cetin, van Os, Gwendolyn M. A., Urbanus, Rolf T., Derksen, Ronald H. W. M., Sprenger, Richard R., Marquart, J. Arnoud, Meijers, Joost C. M., Mörgelin, Matthias,, Lund University., Mörgelin, Matthias, de Groot, Philip G.   +10 more
core   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]

, 2012
Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
Nattkemper, Tim Wilhelm ; https://orcid.org/, Zhou Luxian, Abouna, Sylvie, Julia Herold (136338), James Young (44149), Nattkemper Tim Wilhelm, Abouna Sylvie, Nakhai Hassan, Epstein David, Tim Wilhelm Nattkemper, Herold Julia, Pelengaris Stella, Young, James, Khan, Michael, Stella Pelengaris, Herold, Julia, Nakhai, Hassan, Stella Pelengaris (71018), Hassan Nakhai (136340), Pelengaris, Stella, Sylvie Abouna (71019), Zhou, Luxian, Young James, Luxian Zhou, Michael Khan, Michael Khan (71023), Epstein, David, David Epstein, Luxian Zhou (136331), Hassan Nakhai, Khan Michael, Sylvie Abouna, Epstein, D. B. A., James Young, Nattkemper, Tim W., David Epstein (136335), Tim Wilhelm Nattkemper (136339), Julia Herold   +37 more
core   +1 more source

Structural analysis of human complement protein H: homology with C4b binding protein, beta  2-glycoprotein I, and the Ba fragment of B2. [PDF]

, 1986
Torsten Nygaard Kristensen, Rick A. Wetsel, Brian F. Tack   +2 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice.

, 1994
Beta-2-GPI is a 50 kDa glycoprotein which is known to be a serum co-factor, with a role in determining the binding of pathogenic anticardiolipin antibodies to phospholipids.
Juri Kopolovic, Yehuda Shoenfeld, Flavio Allegri, Iris Goldberg, Angela Tincani, David Faden, Miri Blank, Genesio Balestrieri, VALESINI, Guido, Boris Gilburd   +9 more
core   +1 more source