Results 151 to 160 of about 267,362 (329)

Key Issues at the Forefront of Diagnosis and Testing for Antiphospholipid Syndrome

Clinical and Applied Thrombosis/Hemostasis
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by antiphospholipid antibodies associated with thrombosis and pregnancy complications.
Jesse Qiao MD, Jenique Bailly MBChB, Jessica Opie MBChB   +2 more
doaj   +1 more source

I poeti credevano nelle loro Muse? Atti della giornata di studio, Siena, 2 aprile 2003, a cura di S. Beta.

, 2006
Nel corso dei secoli il ruolo delle Muse ha subito continue oscillazioni, passando da divine garanti dell’ispirazione artistica a figure superflue e fittizie, e viceversa. Eppure le Muse non sono sempre esistite.
Beta, Simone
core  

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

The role of beta 2 glycoprotein I in inflammation and autoimmunity

, 2013
Systemic lupus erythematosus is a multifactorial autoimmune disease which has been associated with several genetic, hormonal and environmental factors. TLRs are a group of innate immune system receptors and have been linked strongly to SLE development.
openaire   +2 more sources

Lesió i protecció de les cèl·lules beta en el trasplantament d'illots pancreàtics [PDF]

, 2007
[cat] El trasplantament d'illots pancreàtics pot ser una bona teràpia per els malalts amb diabetis mellitus de tipus 1, però hi ha alguns problemes que cal solventar abans que sigui un tractament estès.
Montolio Rusiñol, Marta
core  

Studies on beta 2 glycoprotein I and antiphospholipid antibodies

, 2008
Beta 2 glycoprotein I (β2GPI) is a major antigenic target in antiphospholipid syndrome (APS). In vitro studies suggest that it may have multifaceted physiological functions, as it displays both anticoagulant and procoagulant properties. Beta 2GPI may bind to FXI and serve as a regulator of FXI activation by thrombin.
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Role of beta(2)-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects

, 2004
The levels of electronegative low-density lipoprotein (LDL-), LDL cholesterol oxidability, and plasma levels of molecular antioxidants and of beta(2)-glycoprotein I (beta(2) GPI) were studied in a group of 10 hypercholesterolemic (HC) and 10 ...
Alves, A. F., Quirino, L. M., Gomes, L. F., Junqueira, VBC, Sevanian, A., Peres, C. D., Ramos, L. R., Cendoroglo, M. S., De Mello-Almada, C.   +8 more
core   +1 more source

Anti-beta 2-glycoprotein I antibodies: a useful marker for the antiphospholipid syndrome [PDF]

, 1997
Montserrat Teixidó, Josep Font, Joan Carles Reverter, Ricard Cervera, Dolors Tàssies, M Ingelmo, Ginés Escolar, A Ordinas   +7 more
openalex   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source