Results 1 to 10 of about 89,923 (320)

Beta-Adrenergic Receptor Kinase 2 [PDF]

Definitions, 2020
Beta-adrenergic receptor kinase 2 (688 aa, ~80 kDa) is encoded by the human GRK3 gene. This protein plays a role in the regulation of beta-adrenergic receptor-mediated signaling.

semanticscholar   +3 more sources

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. [PDF]

Circulation, 1993
BACKGROUND In chronic heart failure, the positive inotropic effects of beta-adrenergic receptor agonists are greatly reduced, in part as a result of two alterations of the cardiac beta-adrenergic receptors: loss of their function (receptor uncoupling) and reduction of their number (downregulation).
Martin Ungerer, Michael Böhm, John S. Elce, Erland Erdmann, Martin J. Lohse   +4 more
semanticscholar   +6 more sources

Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase. [PDF]

Journal of Clinical Investigation, 1994
Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl ...
Irene García-Higuera, Federico Mayor
semanticscholar   +5 more sources

Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. [PDF]

Journal of Clinical Investigation, 1995
To determine whether beta-adrenergic receptor agonist activation influences guanosine 5'-triphosphate-binding protein (G-protein) expression and beta-adrenergic receptor kinase activity in the heart, we examined the effects of chronic beta 1-adrenergic receptor antagonist treatment (bisoprolol, 0.2 mg/kg per d i.v., 35 d) on components of the ...
Peipei Ping, Ramona Gelzer-Bell, David A. Roth, Douglas P. Kiel, Paul A. Insel, H. Kirk Hammond   +5 more
semanticscholar   +5 more sources

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]

Proceedings of the National Academy of Sciences, 1993
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-adrenergic receptor kinase (beta ARK) is also involved in this process.
Sabine Schleicher, Ingrid Boekhoff, J.L. Arriza, Robert J. Lefkowitz, Heinz Breer   +4 more
semanticscholar   +5 more sources

Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling [PDF]

Breast Cancer Research, 2022
Background Opioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and proliferation of breast cancer cells.
Bénédicte Rousseau, Sengottuvelan Murugan, Ajay Palagani, Dipak K. Sarkar   +3 more
doaj   +2 more sources

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. [PDF]

Proceedings of the National Academy of Sciences, 1996
The beta-adrenergic receptor kinase (betaARK) is the prototypical member of the family of cytosolic kinases that phosphorylate guanine nucleotide binding-protein-coupled receptors and thereby trigger uncoupling between receptors and guanine nucleotide binding proteins.
Rainer Winstel, Stefan M.V. Freund, Cornelius Krasel, E. Hoppe, Martin J. Lohse   +4 more
semanticscholar   +6 more sources

Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system [PDF]

Scientific Reports
Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness globally. The clinical progression of ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms.
Anna Chmielarz-Czarnocińska, Anna Durska, Bartosz Skulimowski, Alicja Sobaniec, Anna Gotz-Więckowska, Ewa Strauss   +5 more
doaj   +2 more sources

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

Proceedings of the National Academy of Sciences of the United States of America, 1986
R. H. Strasser, Jeffrey Benovic, Marc G. Caron, Robert J. Lefkowitz   +3 more
openalex   +2 more sources

Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. [PDF]

Journal of Clinical Investigation, 1995
Antonio De Blasi, Giustino Parruti, Michele Sallese   +2 more
openalex   +2 more sources