Results 1 to 10 of about 57,838 (185)

Prognostic Impact of Concomitant Beta-Blocker Use on Survival in EGFR-Mutant Metastatic Non-Small Cell Lung Cancer Patients Treated with Erlotinib [PDF]

Medicina
Background and Objectives: Erlotinib, a tyrosine kinase inhibitor (TKI), is an established therapy for patients with metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.
Oğuzhan Yıldız, Talat Aykut, Bahattin Engin Kaya, Ömer Genç, Ali Fuat Gürbüz, Fatih Saçkan, Melek Karakurt Eryılmaz, Mehmet Zahid Koçak, Murat Araz, Mehmet Artaç   +9 more
doaj   +2 more sources

In Silico Multitarget Profiling of Non-Selective Beta-Blockers Highlights Their Potential as Key Agents in Breast Cancer Adjuvant Therapy via ADRB2, ERBB2, and NPYR Receptors [PDF]

Current Issues in Molecular Biology
Breast cancer (BC) is associated with multiple molecular factors such as overexpression of the beta-2 adrenergic receptor (ADRB2) and the overproduction of its agonists (norepinephrine and epinephrine).
Felipe Muñoz-González, José Correa-Basurto, Iván Ignacio-Mejia, Cindy Bandala   +3 more
doaj   +2 more sources

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

Proceedings of the National Academy of Sciences of the United States of America, 1996
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors.
Mohamed Jaber, Walter J. Koch, Howard A. Rockman, Bradley D. Smith, Richard A. Bond, Kathleen K. Sulik, John Ross, Robert J. Lefkowitz, Marc G. Caron, Bruno Giros   +9 more
openalex   +2 more sources

Beta-Adrenergic Receptor Kinase 2 [PDF]

Definitions, 2020
Beta-adrenergic receptor kinase 2 (688 aa, ~80 kDa) is encoded by the human GRK3 gene. This protein plays a role in the regulation of beta-adrenergic receptor-mediated signaling.
National Cancer Institute
openalex   +2 more sources

Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling [PDF]

Breast Cancer Research, 2022
Background Opioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and proliferation of breast cancer cells.
Bénédicte Rousseau, Sengottuvelan Murugan, Ajay Palagani, Dipak K. Sarkar   +3 more
doaj   +2 more sources

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. [PDF]

Circulation, 1993
Martin Ungerer, Michael Böhm, John S. Elce, Erland Erdmann, Martin J. Lohse   +4 more
openalex   +2 more sources

Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. [PDF]

Journal of Clinical Investigation, 1995
Antonio De Blasi, Giustino Parruti, Michele Sallese   +2 more
openalex   +2 more sources

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

Proceedings of the National Academy of Sciences of the United States of America, 1996
Rainer Winstel, Stefan M.V. Freund, Cornelius Krasel, E. Hoppe, Martin J. Lohse   +4 more
openalex   +3 more sources

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

Proceedings of the National Academy of Sciences of the United States of America, 1986
Jeffrey Benovic, R. H. Strasser, M G Caron, Robert J. Lefkowitz   +3 more
openalex   +3 more sources

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

Proceedings of the National Academy of Sciences of the United States of America, 1987
Jeffrey Benovic, H. Kühn, Ingo Weyand, Juan Codina, M G Caron, R J Lefkowitz   +5 more
openalex   +3 more sources