Results 1 to 10 of about 58,950 (163)

Prognostic Impact of Concomitant Beta-Blocker Use on Survival in EGFR-Mutant Metastatic Non-Small Cell Lung Cancer Patients Treated with Erlotinib [PDF]

Medicina
Background and Objectives: Erlotinib, a tyrosine kinase inhibitor (TKI), is an established therapy for patients with metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.
Oğuzhan Yıldız, Talat Aykut, Bahattin Engin Kaya, Ömer Genç, Ali Fuat Gürbüz, Fatih Saçkan, Melek Karakurt Eryılmaz, Mehmet Zahid Koçak, Murat Araz, Mehmet Artaç   +9 more
doaj   +2 more sources

Bovine Somatotropin Alters Myosin Heavy Chains and Beta Receptors in Skeletal Muscle of Feedlot Heifers with Little Impact on Live or Carcass Performance

Meat and Muscle Biology, 2021
The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase.
Alex Thompson, Bradley Johnson, Gary Vogel, Jerilyn Hergenreder, Jessica Baggerman, Kari Spivey, Rand Broadway, Tyler Harris, Zachary Smith   +8 more
doaj   +2 more sources

The Potential Anti-remodeling Effect of Paroxetine After Myocardial Infarction May Be Blunted by Beta-Blockers

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI).
Oriol Iborra-Egea, Oriol Iborra-Egea, Alberto Aimo, Alberto Aimo, Nicola Martini, Carolina Galvez-Monton, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Claudio Passino, Michele Emdin, Michele Emdin, Antoni Bayes-Genis, Antoni Bayes-Genis, Antoni Bayes-Genis   +15 more
doaj   +1 more source

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Frontiers in Physiology, 2021
Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang   +5 more
doaj   +1 more source

A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach

Biomolecules, 2021
Obesity is a low-grade systemic inflammatory disease involving adipocytokines. As though Anmyungambi decoction (AMGB) showed significant improvement on obesity in a clinical trial, the molecular mechanism of AMGB in obesity remains unknown. Therefore, we
Dongyeop Jang, Hayeong Jeong, Chang-Eop Kim, Jungtae Leem   +3 more
doaj   +1 more source

Involvement of the Catecholamine Pathway in Glioblastoma Development

Cells, 2021
Glioblastoma (GBM) is the most aggressive tumor of the central nervous system (CNS). The standard of care improves the overall survival of patients only by a few months. Explorations of new therapeutic targets related to molecular properties of the tumor
Zoltán Kraboth, Bela Kajtár, Bence Gálik, Attila Gyenesei, Attila Miseta, Bernadette Kalman   +5 more
doaj   +1 more source

Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting [PDF]

, 2013
Aims: To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype.
A Hirasawa, AC Hanyaloglu, AL Lattion, B Lei, BL Wolfe, C Moyano, C Stenbergen, CD Wright, D Calebiro, D Chalothorn, D Diviani, D Gesty-Palmer, D Wu, DM Perez, DP Morris, DP Morris, E Oliver, EJ Adie, EJ Adie, Elena Carceller, F Liu, Fermí Montó, Graeme Milligan, Ian Christie McGrath, James Porter, JB Morris, JD Pediani, JD Pediani, JL Benovic, John Pediani, KA DeFea, L Stanasila, LM Luttrell, M von Zastrow, María Antonia Noguera, MC Lyssand JS De Fino, Miguel Pérez-Aso, MW Lee, MY Tsang, P Lajoie, PA Patel, Pilar D’Ocon, RH Oakley, RR Price, S Ahn, S Alexander, S Keffel, S Mhaouty-Kodja, S Terrillon, SK Shenoy, SM DeWire, SS Ferguson, TL Theroux, Vanessa Segura, Y Huang   +54 more
core   +7 more sources

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]

PLoS ONE, 2012
The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea, Jennie L Rowell, Yechaowei Li, Tien-Hsien Chang, Carlos E Alvarez   +4 more
doaj   +1 more source

G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line

Breast Cancer: Basic and Clinical Research, 2008
Previous data from our laboratory have indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in breast cancer cell lines and that these pathways ...
Michael W. Hance, Madhu S. Dhar, Howard K. Plummer III   +2 more
doaj   +2 more sources

Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) is an essential regulator for many G protein‐coupled receptors and subsequent
Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Cai   +9 more
doaj   +1 more source