Results 141 to 150 of about 88,568 (304)

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]

, 2015
Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina, Beltran-Alvarez, Pedro, Berne, Paola, Bosch Calero, Cristina, Brugada, Josep, Brugada, Ramon, Campuzano, Oscar, Iglesias, Anna, Pérez, Carmelo, Pérez, Guillermo J., Ruiz Hernandez, Pablo M., Scornik, Fabiana S., Wangüemert, Fernando   +12 more
core   +2 more sources

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]

, 2018
Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core   +1 more source

Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells [PDF]

, 1993
Luteal cells are known to possess receptors for LH/hCG and receptors of the beta-adrenergic type. Interactions of specific agonists with either receptor lead to the activation of adenylate cyclase and subsequently to an increase of cAMP.
Föhr, K. J., Gratzl, Manfred, Mayerhofer, Artur, Rosenbusch, B., Rudolf, M., Sterzik, K.   +5 more
core   +1 more source

Deciphering the panvascular immune landscape of atherosclerosis

VIEW, EarlyView.
Atherosclerosis (AS) involves inflammation in major arteries and can cause severe cardiovascular events like heart attacks and strokes, yet disease patterns vary significantly between arteries, complicating diagnosis and treatment. In this study, we integrated transcriptomic and single‐cell RNA sequencing data from AS plaques across five key arterial ...
Yiming Zhong, Yifan Chen, Yuehong Wang, Wenhai Pan, Honghao Huang, Lin Lin Cao, Yili Wang, Jiawen Zhang, Yunyi Liang, Xiangyue Qian, Chenxi Shi, Xiyuan Lu, Jun Pu   +12 more
wiley   +1 more source

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]

, 2006
Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas, Cirelli, Rosemary, Foster, Gayle C., Hastie, Annette T., Hawkins, Gregory A., Peters, Stephen P., Rybinski, Katherine A., Wu, Min, Zangrilli, James G.   +8 more
core   +1 more source

Probing cellular protein complexes using single-molecule pull-down. [PDF]

, 2011
Proteins perform most cellular functions in macromolecular complexes. The same protein often participates in different complexes to exhibit diverse functionality.
Arauz, Edwin, Chen, Jie, Ha, Taekjip, Ishitsuka, Yuji, Jain, Ankur, Liu, Ruijie, Park, Jeehae, Ragunathan, Kaushik, Ramani, Biswarathan, Xiang, Yang K   +9 more
core   +3 more sources

Propranolol and Oxytocin‐Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin. Design Prospective ex vivo laboratory study. Setting Mount Sinai Hospital, Toronto. Population Full‐term parturients who underwent elective caesarean deliveries (CD).
Mrinalini Balki, Lauren M. Miller, Jayalakshmi Caliaperumal, Stella Wang, Ella Huszti, John C. Kingdom   +5 more
wiley   +1 more source

Alterations of cAMP-dependent signaling in dystrophic skeletal muscle

Frontiers in Physiology, 2013
Autonomic regulation processes in striated muscles are largely mediated by cAMP/PKA-signaling. In order to achieve specificity of signaling its spatial-temporal compartmentation plays a critical role. We discuss here how specificity of cAMP/PKA-signaling
Rüdiger eRudolf, Rüdiger eRudolf, Muzamil Majid Khan, Danilo eLustrino, Siegfried eLabeit, Isis do Carmo Kettelhut, Luiz Carlos Carvalho Navegantes   +6 more
doaj   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source