Results 141 to 150 of about 57,900 (247)

Cardioprotective Mechanisms of Beta-Blockers in Myocardial Ischemia and Reperfusion: From Molecular Targets to Clinical Implications. [PDF]

Int J Mol Sci
Nasoufidou A, Bantidos MG, Fyntanidou B, Kofos C, Stachteas P, Arvanitaki A, Karakasis P, Sagris M, Kassimis G, Fragakis N, Karagiannidis E.   +10 more
europepmc   +1 more source

Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling

MedComm, Volume 6, Issue 11, November 2025.
Proposed model of the interaction of the H3K18la lactylation with GATA4 to promote the cardiac hypertrophy. The image was created using Home for Researchers.com. ABSTRACT Histone lactylation, particularly histone H3 lysine 18 lactylation (H3K18la), modulates gene expression profile in diverse cellular processes, which has emerged as a critical factor ...
Mingzhu Wang, Zixian Liu, Yongbo Ma, Da Li, Yuan Lin, Yani Wang, Deyu Fu, Haidong Guo, Liang Hu   +8 more
wiley   +1 more source

Sildenafil: A Beta-2 Adrenergic Receptor-, Protein Kinase G-, and Protein Kinase A-Dependent Treatment for Adverse Cardiac Function and Excitation-Contraction Coupling Associated with Diabetes [PDF]

, 2018
Toni M. West, Qingtong Wang, Yongming Wang, Federica Barbagallo, Dana Chen, Yang K. Xiang   +5 more
openalex   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Neurotransmitters in tumors: chemical cross-talk shaping tumor progression. [PDF]

Biomark Res
Chen W, Yu J, Ge S, Yuan T, Ding X, Yan B, Ye L, Wang Y, Jia R.   +8 more
europepmc   +1 more source

Mechanism of beta-adrenergic receptor kinase activation by G proteins

, 1993
C.M. Kim, Sarah Dion, Jeffrey Benovic
openalex   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Glucose sensing and homeostasis by adipocyte GPCR. [PDF]

Front Endocrinol (Lausanne)
Hasan N, Chhabra KH.
europepmc   +1 more source

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

, 1993
Madan M. Kwatra, Debra A. Schwinn, Jolanda Schreurs, Jonathan L. Blank, C.M. Kim, Jeffrey Benovic, James E. Krause, Marc G. Caron, Robert J. Lefkowitz   +8 more
openalex   +1 more source

Hyalase in Dermatology: Applications Beyond Filler Management

Journal of Cosmetic Dermatology, Volume 24, Issue 11, November 2025.
ABSTRACT Background Hyaluronic acid (HA) is a key extracellular matrix component in the skin. Hyaluronidase is an enzyme that breaks down HA into monosaccharides. The FDA has approved this enzyme for hypodermoclysis, drug absorption enhancement, and subcutaneous urography.
Saba Hasanzadeh, Parisa Farokh, Golsa Sadat Hosseini, Maryam Abbasian, Ifa Etesami, Shirin Zaresharifi, Sahar Dadkhahfar   +6 more
wiley   +1 more source