Results 11 to 20 of about 88,568 (304)

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. [PDF]

Proceedings of the National Academy of Sciences, 1986
Agonist-promoted desensitization of adenylate cyclase is intimately associated with phosphorylation of the beta-adrenergic receptor in mammalian, avian, and amphibian cells. However, the nature of the protein kinase(s) involved in receptor phosphorylation remains largely unknown.
Jeffrey Benovic, R. H. Strasser, M G Caron, Robert J. Lefkowitz   +3 more
semanticscholar   +4 more sources

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]

Proceedings of the National Academy of Sciences, 1993
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-adrenergic receptor kinase (beta ARK) is also involved in this process.
Sabine Schleicher, Ingrid Boekhoff, J.L. Arriza, Robert J. Lefkowitz, Heinz Breer   +4 more
semanticscholar   +5 more sources

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. [PDF]

Journal of Biological Chemistry, 1994
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the activated form of the beta 2-adrenergic receptor (beta 2AR) and related G protein-coupled receptors. To further elucidate the role of beta ARK in receptor desensitization, we generated a beta ARK dominant negative mutant by converting an invariant lysine residue in the ...
Guanghui Kong, Raymond B. Penn, J.L. Benovic   +2 more
semanticscholar   +4 more sources

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). [PDF]

Proceedings of the National Academy of Sciences, 1987
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. Since this kinase may play an important role in mediating the process of homologous, or agonist-specific, desensitization, we investigated the functional ...
Jeffrey Benovic, H. Kühn, Ingo Weyand, Juan Codina, M G Caron, R J Lefkowitz   +5 more
semanticscholar   +5 more sources

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. [PDF]

Proceedings of the National Academy of Sciences, 1996
The beta-adrenergic receptor kinase (betaARK) is the prototypical member of the family of cytosolic kinases that phosphorylate guanine nucleotide binding-protein-coupled receptors and thereby trigger uncoupling between receptors and guanine nucleotide binding proteins.
Rainer Winstel, Stefan M.V. Freund, Cornelius Krasel, E. Hoppe, Martin J. Lohse   +4 more
semanticscholar   +6 more sources

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

Journal of Biological Chemistry, 1993
The beta gamma subunits of heterotrimeric G proteins play important roles in regulating receptor-stimulated signal transduction processes. Recently appreciated among these is their role in the signaling events that lead to the phosphorylation and subsequent desensitization of muscarinic cholinergic (Haga, K., and Haga, T. (1992) J. Biol. Chem.
Walter J. Koch, James Inglese, W. Carl Stone, Robert J. Lefkowitz   +3 more
semanticscholar   +5 more sources

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

Journal of Biological Chemistry, 1991
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Structural features of this enzyme have been elucidated recently by the isolation of a cDNA that encodes bovine beta ARK.
J.L. Benovic, James J. Onorato, J.L. Arriza, W. Carl Stone, Martin J. Lohse, N.A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Marc G. Caron, Robert J. Lefkowitz   +9 more
semanticscholar   +5 more sources

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. [PDF]

Proceedings of the National Academy of Sciences, 1991
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) and beta-adrenergic receptor kinase (beta ARK), respectively. We report here the cloning of a complementary DNA for RK.
W Lorenz, James Inglese, Krzysztof Palczewski, James J. Onorato, Marc G. Caron, Robert J. Lefkowitz   +5 more
semanticscholar   +4 more sources

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

Journal of Biological Chemistry, 1993
Receptor-specific or homologous desensitization of beta 2-adrenergic receptors is thought to be effected via phosphorylation of the receptor by the beta-adrenergic receptor kinase (beta ARK), followed by binding of beta-arrestin. We have generated stably transfected Chinese hamster ovary cell lines overexpressing either of the two regulatory proteins ...
Susanne Pippig, S Andexinger, Kratika Daniel, Mechthild Puzicha, M G Caron, R J Lefkowitz, Martin J. Lohse   +6 more
semanticscholar   +5 more sources

Beta-Adrenergic Receptor Kinase 2 [PDF]

Definitions, 2020
Beta-adrenergic receptor kinase 2 (688 aa, ~80 kDa) is encoded by the human GRK3 gene. This protein plays a role in the regulation of beta-adrenergic receptor-mediated signaling.

semanticscholar   +3 more sources