Results 51 to 60 of about 88,568 (304)
Antioxidants, 2021 Recent studies have shown that carbonyl stress is a causative factor of schizophrenia, categorized as carbonyl stress-related schizophrenia (CS-SCZ).
Shin Koike +8 more
doaj +1 more source
Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. [PDF]
, 2014 Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and β2-adrenergic receptor (β2AR) in the heart.
Abel, E Dale +14 more
core +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Inhibition of the β-Adrenergic Receptor Kinase by Polyanions
Journal of Biological Chemistry, 1989 The beta-adrenergic receptor kinase, which specifically phosphorylates the agonist-occupied beta-adrenergic receptor, is strongly inhibited by polyanions. Heparin and dextran sulfate inhibit the enzyme with an IC50 of approximately 0.15 microM. De-N-sulfated heparin is approximately 8-fold less potent.
Robert J. Lefkowitz +3 more
openaire +3 more sources
Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]
, 2012 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T. +12 more
core +2 more sources
Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. [PDF]
PLoS ONE, 2012 Glycyrrhetic acid (GA) exerts synergistic anti-asthmatic effects via a β₂-adrenergic receptor (β₂AR)-mediated pathway. Cholesterol is an important component of the structure and function of lipid rafts, which play critical roles in the β₂AR-Gs-adenylate ...
Qian Shi +7 more
doaj +1 more source
Considering the role of Murine double minute 2 in the cardiovascular system [PDF]
, 2019 The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
core +1 more source
Кубанский научный медицинский вестник, 2018 Heart failure is associated with profound sympathetic overactivation, which initially develops as an adaptive effect that supports cardiac contractile function.
O. E. OSADCHII
doaj +1 more source
Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]
, 2016 BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira +4 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1998 Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors.
H. Rockman +7 more
semanticscholar +1 more source