Results 81 to 90 of about 60,329 (293)

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system

Scientific Reports
Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness globally. The clinical progression of ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms.
Anna Chmielarz-Czarnocińska, Anna Durska, Bartosz Skulimowski, Alicja Sobaniec, Anna Gotz-Więckowska, Ewa Strauss   +5 more
doaj   +1 more source

Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells

Archives of Medical Science, 2016
Introduction : It is a widely held view that a progressive reduction of beta-cell mass occurs in the progression of diabetes. RAF-1 kinase and pancreas duodenal homeobox 1 (PDX-1) are major factors that promote survival of cells and maintain normal ...
Sher Zaman Safi, Rajes Qvist, Gracie Ong, Hamed Karimian, Muhammad Imran, Ikram Shah   +5 more
doaj   +1 more source

α1A Adrenoreceptor blockade attenuates myocardial infarction by modulating the integrin-linked kinase/TGF-β/Smad signaling pathways

BMC Cardiovascular Disorders, 2023
Background Myocardial infarction (MI) is considered a public health problem. According to the World Health Organization, MI is a leading cause of death and comorbidities worldwide. Activation of the α1A adrenergic receptor is a contributing factor to the
Nawal M. Alrasheed, Raghad B. Alammari, Tahani K. Alshammari, Maha A. Alamin, Abeer O. Alharbi, Asma S. Alonazi, Anfal F. Bin Dayel, Nouf M. Alrasheed   +7 more
doaj   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Targeting cardiac beta-adrenergic signaling via GRK2 inhibition for heart failure therapy

Frontiers in Physiology, 2013
Cardiac cells, like those of the other tissues, undergo regulation through membrane-bound proteins known as G protein-coupled receptors (GPCRs). β-adrenergic receptors (βARs) are key GPCRs expressed on cardiomyocytes and their role is crucial in cardiac
Alessandro eCannavo, Daniela eLiccardo, Walter J. Koch   +2 more
doaj   +1 more source

COVID‐19 and renin angiotensin aldosterone system: Pathogenesis and therapy

Health Science Reports, 2021
Aims The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binds to the ACE2 component of the renin‐angiotensin aldosterone system (RAAS) and infects the human cells.
Fatemeh Babajani, Atefeh Kakavand, Hossien Mohammadi, Armin Sharifi, Saba Zakeri, Soheila Asadi, Zeinab Mohseni Afshar, Zohreh Rahimi, Babak Sayad   +8 more
doaj   +1 more source

Higenamine Attenuates Doxorubicin-Induced Cardiac Remodeling and Myocyte Apoptosis by Suppressing AMPK Activation

Frontiers in Cell and Developmental Biology, 2022
Background: As an effective antitumor drug, doxorubicin (DOX) is primarily used to treat solid tumors and hematologic malignancies. However, increasing evidence has emerged indicating its cardiotoxicity, and few solutions have been proposed to counter ...
Cuiliu Jin, Yu Chai, Zhimin Hu, Wencong Tian, Wang Ling, Jing Li, Meiping Wu   +6 more
doaj   +1 more source

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]

, 2018
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Grisanti, Laurel A., Koch, Walter J., Thomas, Toby P., Tilley, Douglas G.   +7 more
core   +1 more source