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Amyloid Beta: The Alternate Hypothesis
Current Alzheimer Research, 2006Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the ...
Hyoung-gon, Lee +4 more
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The international journal of biochemistry & cell biology, 1999
Amyloid beta (A beta) is a 39-43 residue amyloidogenic peptide that is deposited into the extracellular amyloid plaques which characterize an Alzheimer's disease (AD) brain. A beta is derived from the amyloid precursor protein (APP) and undergoes a toxic conformational change (gain of toxic function).
R, Cappai, A R, White
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Amyloid beta (A beta) is a 39-43 residue amyloidogenic peptide that is deposited into the extracellular amyloid plaques which characterize an Alzheimer's disease (AD) brain. A beta is derived from the amyloid precursor protein (APP) and undergoes a toxic conformational change (gain of toxic function).
R, Cappai, A R, White
openaire +1 more source
Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor
Journal of Alzheimer's Disease, 2002Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling +4 more
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Amyloid and the Cross-Beta Architecture
Journal of Visualized ExperimentsAmyloid fibrils are made up of a misfolded, self-assembled protein organised into a well-defined, repetitive structure. They are well known for their important role in protein misfolding diseases, including Alzheimer's disease and type 2 diabetes, in which the insoluble amyloid fibrils are deposited in the tissues.
Kyle, Morris +4 more
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Beta-amyloid immunisation in Alzheimer’s disease
Neurological Sciences, 2005Beta-amyloid immunisation in Alzheimer's ...
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Amyloid Beta in Aging and Alzheimer’s Disease
International Journal of Molecular Sciences, 2022Jonathan Kopel +2 more
exaly
Brain : a journal of neurology, 2003
The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
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The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du +9 more
openaire +1 more source