Results 41 to 50 of about 1,107,303 (283)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Steven N. Johnson, Lin Xu, William Banks, Kelvin A. Yamada, Susan Farr   +5 more
core  

Plasma Amyloid-β Oligomerization Tendency Predicts Amyloid PET Positivity

Clinical Interventions in Aging, 2021
Jung-Min Pyun,1 Ji Sun Ryu,2 Ryan Lee,2 Kyu Hawn Shim,3 Young Chul Youn,4 Nayoung Ryoo,5 Sang-Won Han,5 Young Ho Park,5 Sungmin Kang,2 Seong Soo A An,6 SangYun Kim5 1Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu-si,
Pyun JM, Ryu JS, Lee R, Shim KH, Youn YC, Ryoo N, Han SW, Park YH, Kang S, An SS, Kim SY   +10 more
doaj  

The Effect of 24-Hydroxy Cholesterol on Production of Reactive Oxygen Species (ROS) in Cultured Astrocytes Treated by Beta Amyloid

مجله دانشکده پزشکی اصفهان, 2018
Background: Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of beta-amyloid plaques outside the cells, and intracellular hyperphosphorylation of tau protein.
Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Bahar Sepiani, Alireza Kheirollah   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

In-vitro interaction studies between the amyloid PET tracer florbetaben and the amyloid-beta targeting antibodies lecanemab and donanemab on AD brain samples reveal no interferences

Alzheimer’s Research & Therapy
Background Amyloid PET imaging enables the in vivo visualization and quantification of amyloid-beta deposits in the brain. In research and clinical settings, it is further used to monitor amyloid-beta burden as well as the biological response to disease ...
Andre Mueller, Aleksandar Jovalekic, Marianne Chapleau, Julius Seidel, Maria Ritter, Eva-Maria Bickel, Nadine Kiessling, Emer MacSweeney, Andrew W. Stephens, Norman Koglin   +9 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]

, 2005
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Jeremy P., Bradshaw, Jeremy, Hauss, T, Ashley, Richard H., Balali-Mood, K, Bradshaw, J. P., Balali-Mood, K., Hauß, Thomas, Ashley, R.H., Balali-Mood, Kia, Ashley, R. A., Ashley, R H, Balali Mood, K., Hau , T., Bradshaw, J.P.   +14 more
core   +1 more source

Obstructive sleep apnea and amyloid-β42 in adolescents: The results of a pilot study

Acta Biomedica Scientifica, 2022
Background. Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive collapse of the upper airway during sleep leading to intermittent hypoxia, excessive arousals and disrupt of sleep homeostasis. OSA is associated with obesity as
O. N. Berdina, I. M. Madaeva, S. E. Bolshakova, L. F. Sholokhov, L. V. Rychkova   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source