Results 131 to 140 of about 189,690 (343)

Outcomes Assessment and Health Care Reform [PDF]

, 2008
Argues for the use of outcomes assessment in measuring cost-effectiveness and quality to capture the overall impact of multi-dimensional treatment strategies and to identify healthcare systems that both adopt appropriate technologies and perform ...
Amitabh Chandra, Elliott S. Fisher, Jonathan S. Skinner   +2 more
core  

Clinical impact of selective and nonselective beta‐blockers on survival in patients with ovarian cancer [PDF]

, 2015
Jack L. Watkins, Premal H. Thaker, Alpa M. Nick, Lois M. Ramondetta, Sanjeev Kumar, Diana L. Urbauer, Koji Matsuo, Kathryn C. Squires, Robert L. Coleman, Susan K. Lutgendorf, Pedro T. Ramírez, Anil K. Sood   +11 more
openalex   +1 more source

Evaluation of ivabradine plus beta-blocker versus beta-blocker alone in addition to standard care in reducing hospitalization and major adverse cardiovascular event in patients with chronic heart failure: a prospective observational study in tertiary care hospital in central India

The Egyptian Heart Journal
Background In recent years, there has been an increase in cases of heart failure, ultimately leading to an increase in hospitalization for heart failure (HF) and cardiovascular mortality. The aim of our study was to evaluate ivabradine combined with beta-
Ramyaa Desingu, Shilpa Kaore, Gaurav Kandelwal, S. Balakrishnan   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

What is the best treatment for hypertension in African Americans? [PDF]

, 2007
In African Americans with hypertension, therapy is best initiated with the low-sodium Dietary Approaches to Stop Hypertension (DASH) diet and a thiazide-type diuretic (strength of recommendation [SOR]: A, based on randomized controlled trials).
Cherukuri, Manjula, Mayo, Helen G., Rao, Shobha   +2 more
core  

Effect of Beta-Blockers on Stroke Outcome: A Meta-Analysis

, 2021
Balla HZ, Cao Y, Ström JO
openalex   +1 more source

Beta-blocker treatment in heart failure patients with atrial fibrillation: challenges and perspectives.

, 2021
Emmanouil Chourdakis, Ioanna Koniari, Dimitrios Velissaris, Grigorios Tsigkas, Nikolaos Kounis, Neriman Osman   +5 more
openalex   +2 more sources

Effect of beta‐blockade on mortality in patients with cardiac amyloidosis: A systematic review and meta‐analysis

ESC Heart Failure
Aims The efficacy of beta‐blockers in cardiac amyloidosis (CA) is unclear, and concerns persist that neurohormonal blockade could worsen symptoms of heart failure.
Chun Shing Kwok, Chern Hsiang Choy, Jennifer Pinney, Jonathan N. Townend, Carol Whelan, Marianna Fontana, Julian D. Gillmore, Richard P. Steeds, William E. Moody   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source