Results 141 to 150 of about 189,690 (343)

Which patients undergoing noncardiac surgery benefit from perioperative beta-blockers? [PDF]

, 2008
Patients with moderate to high cardiac risk (a Revised Cardiac Risk Index [RCRI] score of 2 or higher [Table]) have a reduced risk of in-hospital death following perioperative beta-blocker therapy (strength of recommendation [SOR]: B, based on a large ...
Haynes, Jamie, Jamieson, Barbara, Kelsberg, Gary   +2 more
core  

Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis

, 2019
Jeffrey L. Jackson, Akira Kuriyama, Yachiyo Kuwatsuka, Sarah Nickoloff, Derek Storch, Wilkins Jackson, Zhi-Jiang Zhang, Yasuaki Hayashino   +7 more
openalex   +2 more sources

5936Beneficial effect of beta-blockers on clinical outcomes persist after discontinuation in patients with ST elevation myocardial infarction? [PDF]

, 2017
J.-S. Park, Kyoung‐Woo Seo, Hyoung‐Mo Yang, Hong‐Seok Lim, Byoung‐Joo Choi, So‐Yeon Choi, Myeong‐Ho Yoon, Gyo‐Seung Hwang, Seung‐Jea Tahk, Joon‐Han Shin   +9 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Meta-analysis of the effects of beta blocker on survival time in cancer patients

, 2014
Chel Hun Choi, Taejong Song, Tae Hyun Kim, Jun Kuk Choi, Jin‐Young Park, Aera Yoon, Yoo-Young Lee, Tae‐Joong Kim, Duk‐Soo Bae, Jeong‐Won Lee, Byoung‐Gie Kim   +10 more
openalex   +2 more sources

Beta-blocker therapy in patients with left ventricular systolic dysfunction and chronic obstructive lung disease in an ambulatory care setting

Pharmacy Practice, 2009
Objective: To evaluate beta blocker persistence six months after beta-blocker initiation or dose titration in heart failure (HF) patients with COPD compared to those without COPD.
Billups SJ, Delate T, Schimmer JJ
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A case of continuous ventricular tachycardia after radical operation of teratology of Fallot in which combined use of flecainide and .BETA. blocker was effective.

, 1991
Masahiro Usui
openalex   +2 more sources