Results 91 to 100 of about 865,952 (246)
Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]
, 2010 Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan +3 more
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PLoS Biology, 2010 In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of beta-catenin, which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes.
Dimple Notani +8 more
doaj +1 more source
Advanced Science, EarlyView.In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu +16 more
wiley +1 more source
EGFR and WNT/β-catenin signalling in airway homeostasis and repair [PDF]
, 2011 Lung cancers are a leading cause of death worldwide, and although there is some evidence that both Epidermal Growth Factor Receptor (EGFR) and Wnt/β-catenin signalling are involved in initiation and progression of this disease the molecular mechanisms
Lu, L.
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Drug Design, Development and Therapy, 2019 Xianhua Huang*, Zhixi Chen*, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu, Longhuo WuCollege of Pharmacy, Gannan Medical University, Ganzhou, People’s Republic of China*These authors contributed equally to this work Background: miR-29a, a downstream ...
Huang X +6 more
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Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
The role of the transcription factor Sox9 for thymic epithelial cell differentation and function [PDF]
, 2011 The thymus provides throughout life the specialized stromal microenvironment required for the lifelong generation of naïve T cells. This vital function is dependent on the regular composition and organization of its microenvironment, where specialized ...
Žalac, Tatjana
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Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
An examination of VEGF, its receptors and the adherens junction component, β-catenin in the development of primary varicose veins [PDF]
, 2010 Vascular endothelial growth factor (VEGF-A) plays a central role in the maintenance of vascular reactivity and its aberrant control/function is implicated in the development of varicose veins (VVs).
Powell, G.L.
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